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BDKRB2 antibody

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Principal name

BDKRB2 antibody

Alternative names for BDKRB2 antibody

B2 bradykinin receptor, BKR2, BK-2 receptor, B2R, B1BKR

SwissProt ID

P25023 (Rat), P30411 (Human), P32299 (Mouse), Q9GLX8 (Pig)

Gene ID

624 (BDKRB2), 12062 (Bdkrb2), 25245

Ncbi ID

NP_000614.1, 9606, NP_000614, NM_009747, NM_173100

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of BDKRB2 antibody

Kinins are small peptides produced rapidly following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) seem to initiate a similar cascade of events leading to neural tissue damage, as well as long lasting disturbances affecting blood-brain barrier function. Kinins, such as Bradykinin (BK), Lys-BK, desArg-BK, and Lys-desArg-BK, exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). BKRB2 is activated by BK and Lys-BK while desArg-BK and Lys-desArg-BK activate BKRB1. Activation of BKRB2 liberates mediators of vascular tone, fibrinolysis, and pain. BKRB2, which mediates most of the physiological effects of kinins, as well as BKRB1, represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases. Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxy terminus. BKRB2 is constitutively and widely expressed throughout the CNS and peripheral nervous system and on various cell types including endothelial cells, nerve fibers, leukocytes, and mast cells.

General readings

Michineau,S., (2006) Biochemistry 45 (8), 2699-2707

SP4078P - BDKRB2
Formalin-Fixed, Paraffin-Embedded Human Brain, Neurons and Glia stained with BDKRB2 Antibody Cat.-No SP4078P after heat-induced antigen retrieval.
SP4078P - BDKRB2
Formalin-Fixed, Paraffin-Embedded Human Prostate stained with BDKRB2 Antibody Cat.-No SP4078P.
SP4078P - BDKRB2
Immunocytochemistry staining of untransfected HEK293 human embryonic kidney cells with BDKRB2 Antibody Cat.-No SP4078P.
SP4078P - BDKRB2
Immunocytochemistry staining of HEK293 human embryonic kidney cells transfected with BDKRB2 Antibody Cat.-No SP4078P.
H00000624-M01 - BDKRB2
Detection limit for recombinant GST tagged BDKRB2 is approximately 0.1ng/ml as a capture antibody.
ARP41781_T100 - BDKRB2
Human Jurkat; WB Suggested Anti-BDKRB2 Antibody Titration: 5.0ug/ml. Positive Control: Jurkat cell lysate; BDKRB2 antibody - N-terminal region (ARP41781_T100) in Human Jurkat cells using Western Blot
AP32712SU-N - BDKRB2
Immunofluorescent detection of Bradykinin R2 in Rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence).
AP32713PU-N - BDKRB2
Human Jurkat; WB Suggested Anti-BDKRB2 Antibody Titration: 5.0ug/ml. Positive Control: Jurkat cell lysate; BDKRB2 antibody - N-terminal region (AP32713PU-N) in Human Jurkat cells using Western Blot
TA321167 - BDKRB2
Predicted band size: 44kDa. Positive control: Human leiomyosarcoma tissue and NIH/3T3 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: Human leiomyosarcoma tissue lysate Lane2: NIH/3T3 cell lysate Lysates: 50 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute)
TA321167 - BDKRB2
Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue . Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using BDKRB2 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200)
TA321168 - BDKRB2
Predicted band size: 45 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
TA321168 - BDKRB2
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human colon cancer tissue . Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using BDKRB2 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x200)
TA328719 - BDKRB2
Western blot analysis of rat brain lysate: 1. Anti-B2 Bradykinin Receptor antibody, (1:1000). 2. Anti-B2 Bradykinin Receptor antibody, preincubated with the control peptide antigen.
TA328719 - BDKRB2
Expression of B2 Bradykinin Receptor in mouse spinal cord. Immunohistochemical staining of mouse spinal cord using Anti-B2 Bradykinin Receptor antibody . A. B2 Bradykinin Receptor (red) appears in several spinal cord neurons (triangles). B. Parvalbumin (green) appears in neurons. C. Merge of B2 Bradykinin Receptor and parvalbumin shows co-expression in several neurons (triangles) but not all (arrow in C). DAPI is used as the counterstain.
TA346209 - BDKRB2
WB Suggested Anti-BDKRB2 Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BDKRB2 (C-term) antibody
Formalin-Fixed, Paraffin-Embedded Human Brain, Neurons and Glia stained with BDKRB2 Antibody Cat.-No SP4078P after heat-induced antigen retrieval. Rabbit Aff - Purified Hu ICC/IF, P
50 µg / €425.00
  OriGene Technologies GmbH
+3 additional images

Published recently!

Highly validated antibody!

BDKRB2 antibody
  Anti-BDKRB2 rabbit polyclonal antibody  
Predicted band size: 44kDa. Positive control: Human leiomyosarcoma tissue and NIH/3T3 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: Human leiomyosarcoma tissue lysate Lane2: NIH/3T3 cell lysate Lysates: 50 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

BDKRB2 antibody
  Anti-BDKRB2 Rabbit Polyclonal Antibody  
Predicted band size: 45 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

BDKRB2 antibody
  Rabbit Polyclonal Anti-B2 Bradykinin Receptor  
Western blot analysis of rat brain lysate: 1. Anti-B2 Bradykinin Receptor antibody, (1:1000). 2. Anti-B2 Bradykinin Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+1 additional image

BDKRB2 antibody
Immunofluorescent detection of Bradykinin R2 in Rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence). Rabbit Serum Ms, Rt C, ICC/IF
0.1 ml / €270.00
  OriGene Technologies GmbH

BDKRB2 antibody
Immunofluorescent detection of Bradykinin R2 in rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence). Rabbit Serum Ms, Rt C, ICC/IF
0.1 ml / €270.00
  Neuromics Antibodies

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Bdkrb2 (GFP-tagged ORF) - Rat bradykinin receptor B2 (Bdkrb2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Bdkrb2 (GFP-tagged ORF) - Rat bradykinin receptor B2 (Bdkrb2), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Bdkrb2 (Myc-DDK-tagged ORF) - Rat bradykinin receptor B2 (Bdkrb2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Bdkrb2 (Myc-DDK-tagged ORF) - Rat bradykinin receptor B2 (Bdkrb2), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

8 Item(s)

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Available Filters

Product Type
  1. Primary Antibody (6)
  2. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (6)
Target
  1. BDKRB2 (6)
Property
  1. C-term (1)
Reactivity
  1. Mouse (Ms) (5)
  2. Rat (Rt) (5)
  3. Human (Hu) (4)
Applications
  1. Immunocytochemistry/​Immunofluorescence (ICC/IF) (4)
  2. Paraffin Sections (P) (3)
  3. Western blot / Immunoblot (WB) (3)
  4. Frozen sections (C) (2)
  5. Enzyme Immunoassay (E) (2)
Presentation
  1. Purified (3)
  2. Serum (2)
  3. Aff - Purified (1)
Host
  1. Rabbit (6)
Images
  1. 1 image (6)
  2. 3+ images (1)
Images: Applications
  1. Immunocytochemistry/​Immunofluorescence (ICC/IF) (3)
  2. IHC (3)
  3. Western blot / Immunoblot (WB) (3)
  4. Paraffin Sections (P) (1)
Manufacturer
  1. OriGene Technologies (7)
  2. Neuromics Antibodies (1)
Service
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