Beta-glucuronidase antibody
Principal name
Beta-glucuronidase antibody
Alternative names for Beta-glucuronidase antibody
GUSB, Beta-G1
SwissProt ID
O18835 (Canfa), O97524 (Felca), P05804 (Ecoli), P06760 (Rat), P08236 (Human), P12265 (Mouse), Q4FAT7 (Pig)
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R), Flow Cytometry (F), ELISA (detection) (E(detection)), Frozen Sections (C)
Background of Beta-glucuronidase antibody
GUSB(Beta-Glucuronidase) is an enzyme that in humans is encoded by the GUSB gene. The GUSB gene encodes beta-glucuronidase, a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans. It is a tetrameric glycoprotein composed of identical subunits. The GUSB gene is mutated in mucopolysaccharidosis type VII. Miller et al. (1990) reported that the GUSB gene is 21 kb long and contains 12 exons. The GUSB gene is mapped on 7q11.21. Beta-glucuronic acid acts naturally to cleave glucuronides from conjugated bilirubin to produce unconjugated bilirubin, which is then absorbed into the bloodstream.Kreamer et al. (2001) postulated that the beta-glucuronidase inhibitor L-aspartic acid can thus block enterohepatic circulation of bilirubin. Tomatsu et al. (2002) stated that more than 45 different mutations in the GUSB gene had been identified in human patients with MPS VII, approximately 90% of which were point mutations.
General readings
Tomatsu,S. Hum. Mutat. 30 (4), 511-519 (2009)
Romanowski,T. Med. Sci. Monit. 14 (7), BR147-BR152 (2008)
Gratz,M. Pharmacogenet. Genomics 15 (12), 875-881 (2005)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA313989 | Beta-glucuronidase antibody |
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| Rabbit polyclonal anti-GUSB antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP51986PU-N | Beta-glucuronidase (Center) antibody |
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 |
Rabbit | Ig | Aff - Purified | Hu, Por | F, P, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
 +2 additional images |
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| AP51987PU-N | Beta-glucuronidase (C-term) antibody |
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 |
Rabbit | Ig | Aff - Purified | Hu | P, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP304325 | Beta-glucuronidase |
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| Recombinant protein of human glucuronidase, beta (GUSB) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY400064 | GUSB overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR209794L2V | Lenti ORF particles, Gusb (GFP-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,390.00
|
|
| OriGene Technologies, Inc. | ||
| RR209794L1V | Lenti ORF particles, Gusb (Myc-DDK-tagged ORF) - Rat glucuronidase, beta (Gusb), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,250.00
|
|
| OriGene Technologies, Inc. | ||