BTK antibody
Principal name
BTK antibody
Alternative names for BTK antibody
Bruton tyrosine kinase, AGMX1, ATK, BPK, Tyrosine-protein kinase BTK, Agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase
Ncbi ID
9606, NP_000052.1, NP_000052, NM_000061, Q06187, NP_038510.2
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Luminex (LMNX), Frozen Sections (C)
Background of BTK antibody
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.





























































































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- Cited (1)
- Highly Validated (10)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA501118 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI10E10 (formerly 10E10) | |||||||
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Mouse | IgG2a | OTI10E10 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Top Selling product! Published recently! Highly validated antibody! |
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| TA336560 | BTK antibody |
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| Mouse Monoclonal BTK Antibody (7F12H4) | |||||||
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Mouse | IgG1 | 7F12H4 | Purified | Hu, Prim | C, E, ICC/IF, P, WB |
0.1 ml /
€395.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA501090 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI12D4 (formerly 12D4) | |||||||
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Mouse | IgG2a | OTI12D4 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| TA501091 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI12H4 (formerly 12H4) | |||||||
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Mouse | IgG3 | OTI12H4 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| TA501092 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI3D11 (formerly 3D11) | |||||||
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Mouse | IgG3 | OTI3D11 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| TA501093 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI6H9 (formerly 6H9) | |||||||
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Mouse | IgG2b | OTI6H9 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| TA501094 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI3A2 (formerly 3A2) | |||||||
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Mouse | IgG1 | OTI3A2 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+9 additional images |
Highly validated antibody! |
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| TA501100 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI3E9 (formerly 3E9) | |||||||
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Mouse | IgG1 | OTI3E9 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA501101 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI1H7 (formerly 1H7) | |||||||
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Mouse | IgG1 | OTI1H7 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| TA501119 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI15G8 (formerly 15G8) | |||||||
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Mouse | IgG1 | OTI15G8 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€379.00
|
| OriGene Technologies, Inc. | |||||||
+6 additional images |
Highly validated antibody! |
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| TA306188 | BTK (N-term) antibody |
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| Rabbit Polyclonal BTK Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms | E, ICC/IF, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA309594 | BTK antibody |
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| Rabbit Polyclonal BTK [p Tyr223] Antibody | |||||||
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Rabbit | Purified | Hu, Ms | C, ICC/IF, WB |
0.1 ml /
€590.00
|
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| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA313379 | BTK antibody |
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| Rabbit polyclonal BTK (Ab-222) antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA327086 | BTK antibody |
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| BTK Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
|
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| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA346898 | BTK antibody |
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| Mouse Monoclonal BTK Antibody | |||||||
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Mouse | IgG1 | 5B12-C9-F10 | Purified | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA348449 | BTK antibody |
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| Rabbit Polyclonal Anti-Phospho-BTK(Tyr223) Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA501102 | BTK antibody |
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| anti-BTK mouse monoclonal antibody, clone OTI13E5 (formerly 13E5) | |||||||
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Mouse | IgG2a | OTI13E5 | Purified | Hu | F, ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA600509 | BTK antibody |
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| Luminex validated purified BTK mouse monoclonal antibody (clone 1H7, clone OTI1H7 (formerly 1H7) | |||||||
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Mouse | IgG1 | OTI1H7 | Purified | Hu | LMNX |
0.1 mg /
€350.00
|
| OriGene Technologies, Inc. | |||||||
| TA600510 | BTK antibody |
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| Luminex validated purified BTK mouse monoclonal antibody (clone 6H9, clone OTI6H9 (formerly 6H9) | |||||||
![]() |
Mouse | IgG1 | OTI6H9 | Purified | Hu | LMNX |
0.1 mg /
€350.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA600511 | BTK antibody |
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| Luminex validated purified BTK mouse monoclonal antibody (clone 10E, clone OTI10E10 (formerly 10E10) | |||||||
![]() |
Mouse | IgG1 | OTI10E10 | Purified | Hu | LMNX |
0.1 mg /
€350.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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+5 additional images
![Western Blot: BTK Antibody (7F12H4) [TA336560] - Analysis of BTK expression in 1) truncated BTK recombinant protein and 2) K562 cell lysate.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB110-87047-1-W.jpg)

















