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CABP1 antibody

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Principal name

CABP1 antibody

Alternative names for CABP1 antibody

Calcium-binding protein 1, Calbrain

SwissProt ID

O88751 (Rat), Q9JLK7 (Mouse), Q9N1R0 (Bovin), Q9NZU7 (Human)

Gene ID

9478 (CABP1), 171051 (Cabp1), 29867

Ncbi ID

9606, NM_031205, NP_112482, NP_112482.1, NP_001028847.1, NM_013879, NM_001033675, NM_001033676, NM_004276

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CABP1 antibody

Neurol Ca2+-binding proteins (CaBP1-5) are a subclass of the calmodulin (CaM) superfamily that regulates specific Ca2+ channel targets in the brain and reti. Multiple isoforms of CaBPs are localized in different neurol cell types and perform specialized roles in sensory transduction and disease processes. CaBP1–5 proteins have four EF hands that form pairs within the N lobe (EF1 and 2) and C lobe (EF3 and 4). The two lobes are structurally independent and connected by a flexible linker. Whereas all four EF hands bind Ca2+ in CaM, EF2 in CaBP1 does not bind Ca2+, and EF1 has reduced selectivity for Ca2+ over Mg2+. EF3 and EF4 in the C lobe of CaBP1 exhibit canonical Ca2+-induced conformatiol changes. CaBP-target interactions induce functiol changes distinct from those caused by CaM and may diversify neurol responses to Ca2+ sigls. CaBPs interact with and reshape the functiol properties of certain voltage-gated Ca2+ channels (CaVs). CaBP1 is the best characterized family member and has been shown to regulate inositol 1,4,5-triphosphate receptors (IP3Rs), P/Q-type voltage-gated Ca2+ channels, L-type Ca2+ channels, and the transient receptor potential channel (TRPC5). CaBP1 regulates the currents of CaV1 and CaV2 channels in neurons, photoreceptors, and auditory hair cells. CaBP interactions with CaV1 channels may be required for hearing and vision, as mutations that disrupt these interactions cause blindness and deafness.

General readings

Yamaguchi K, Yamaguchi F, Miyamoto O, Sugimoto K, Konishi R, Hatase O, Tokuda M.
Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain.
J Biol Chem 1999 Feb 5;274(6):3610-6
PMID: 9920909

PAB6223 - CABP1
CABP1 polyclonal antibody ( Cat # PAB6223 ) staining ( 1 µg/ml ) of human brain lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
AP14245PU-N - CABP1
Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
AP14245PU-N - CABP1
Western blot analysis of anti-CABP1 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).CABP1(arrow) was detected using the purified Pab (1:60 dilution).
TP318317 - CABP1
TA302818 - CABP1
TA302818 staining (1µg/ml) of human brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
TA328795 - CABP1
Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) membranes: 1, 2. Anti-Calcium-binding protein 1 antibody, (1:600). 3, 4. Anti-Calcium-binding protein 1 antibody preincubated with the control antigen.
CPA9250-100ul - CABP1
Western blot analysis of CABP1 expression in mouse brain (A); rat brain (B) whole cell lysates.
CPA9250-100ul - CABP1
Immunohistochemical analysis of CABP1 staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CABP1 (N-term) antibody
  Goat Polyclonal Antibody against CABP1  
TA302818 staining (1µg/ml) of human brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

CABP1 antibody
  Rabbit Polyclonal Anti-Calcium-Binding Protein 1  
Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) membranes: 1, 2. Anti-Calcium-binding protein 1 antibody, (1:600). 3, 4. Anti-Calcium-binding protein 1 antibody preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.

CABP1 (C-term) antibody
Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+1 additional image

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CABP1 (transcript variant 1)
  Recombinant protein of human calcium binding protein 1 (CABP1), transcript variant 1  
CABP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

Lysates

Catalog No.    

CABP1 overexpression lysate
CABP1 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cabp1 (GFP-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 2, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cabp1 (GFP-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cabp1 (GFP-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cabp1 (GFP-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cabp1 (Myc-DDK-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 2, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cabp1 (Myc-DDK-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cabp1 (Myc-DDK-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cabp1 (Myc-DDK-tagged ORF) - Rat calcium binding protein 1 (Cabp1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

9 Item(s)

per page

Available Filters

Product Type
  1. Lysate (1)
  2. Primary Antibody (3)
  3. Protein | Growth Factor (1)
  4. Rat Lenti ORF Particle (4)
Clonality
  1. Polyclonal (3)
Target
  1. CABP1 (4)
Property
  1. C-term (1)
  2. N-term (1)
Reactivity
  1. Human (Hu) (3)
  2. Mouse (Ms) (1)
  3. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Paraffin Sections (P) (1)
Presentation
  1. Purified (2)
  2. Aff - Purified (1)
Host
  1. Rabbit (2)
  2. Goat (1)
Images
  1. 1 image (4)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Paraffin Sections (P) (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (9)
Service
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