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CACNA1B antibody

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Principal name

CACNA1B antibody

Alternative names for CACNA1B antibody

CACH5, CACNL1A5, Cav2.2, Brain calcium channel III, Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-gated calcium channel subunit alpha, Calcium channel L type alpha-1 polypeptide isoform 5

SwissProt ID

O55017 (Mouse), O73706 (Chick), Q00975 (Human), Q02294 (Rat)

Gene ID

774 (CACNA1B), 12287 (Cacna1b), 257648

Ncbi ID

NP_000709.1, 10090, 10116, NP_001035993.1

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CACNA1B antibody

Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; a1, Ã?, a2d and ?. CaV channels were origilly divided into six physiological types: L, N, P, Q, R, and T type.The CaV2.2 (formally med a1B) composes the a1 poreforming subunit for the N type Ca2+ channel family. They are involved in neurotransmitter release from central neurons, including glutamate, ?-aminobutyric acid, acetylcholine, dopamine and noradreline.The CaV2.2 is expressed preferentially in the central nervous system, where along with CaV2.1, it is responsible for pre-syptic Ca2+ influx and neurotransmitter release.The CaV2.2 channel is negatively regulated by many different GPCRs. There are two ways that this is done: either by directly binding GÃ?? to the channel or by an indirect mechanism involving second messenger and channel phosphorylation.?-Conotoxin GVIA is a specific blocker of Cav2.2 Ca2+ channels. It specifically blocks N-type Cav channels by binding to the Cav2.2 a1 subunit (a1B) and its action is only partially reversible.

TA308673 - CACNA1B
CACNA1B antibody [C3], C-term detects CACNA1B protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. 5 % SDS-PAGE. CACNA1B antibody [C3], C-term (TA308673) dilution: 1:500
TA308673 - CACNA1B
Immunofluorescence analysis of methanol-fixed A549, using CACNA1B(TA308673) antibody at 1:500 dilution.
TA308673 - CACNA1B
Figure from citation: Immunoprecipitation of CACNA1B(Cav2.2) protein level by using anti-CACNA1B antibody in rat dorsal root ganglia. View Citation
TA328722 - CACNA1B
Western blot analysis of rat brain membranes: 1. Anti-CaV2.2 antibody, (1:200). 2. Anti-CaV2.2 antibody, preincubated with the control antigen.
TA328722 - CACNA1B
Expression of Cav2.2 in mouse cerebellum. Immunohistochemical staining of mouse cerebellum with Anti-Cav2.2 antibody, (1:100). A. Cav2.2 (red) appears in Purkinje cells (arrows) and is distributed diffusely in the molecular layer (Mol). B. Staining of Purkinje cells with mouse anti-Calbindin 28K (green) demonstrates the restriction of Cav2.2 to cell bodies but not to dendrites in the molecular layer. C. Merged image of panels A and B.
TA328722 - CACNA1B
Expression of Cav2.2 in rat DRG primary culture. Immunocytochemical staining of paraformaldehyde-fixed and permeabilized rat dorsal root ganglion (DRG) primary culture. A. Cells were stained using Anti-Cav2.2 antibody, (1:200) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. B. Nuclear fluorescence staining of cells using the membrane-permeable DNA dye Hoechst 33342. C. Merged images of panels A and B.

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA1B antibody
  Rabbit polyclonal antibody to CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit)  
CACNA1B antibody [C3], C-term detects CACNA1B protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. 5 % SDS-PAGE. CACNA1B antibody [C3], C-term (TA308673) dilution: 1:500 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €415.00
  OriGene Technologies, Inc.
+2 additional images

CACNA1B antibody
  Rabbit Polyclonal Anti-CaV2.2  
Western blot analysis of rat brain membranes: 1. Anti-CaV2.2 antibody, (1:200). 2. Anti-CaV2.2 antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+2 additional images

CACNA1B antibody
CACNA1B Rabbit IgG Purified Hu WB
0.1 mg / €400.00
  OriGene Technologies GmbH

CACNA1B (alpha-1) antibody
CACNA1B Rabbit Purified Hu C, E, WB
0.1 mg / €450.00
  OriGene Technologies GmbH

4 Item(s)

per page

Available Filters

Product Type
  1. Primary Antibody (4)
Clonality
  1. Polyclonal (4)
Target
  1. CACNA1B (4)
Property
  1. alpha-1 (1)
Reactivity
  1. Human (Hu) (4)
  2. Mouse (Ms) (1)
  3. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Frozen sections (C) (1)
  3. Enzyme Immunoassay (E) (1)
  4. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
Presentation
  1. Purified (3)
  2. Aff - Purified (1)
Host
  1. Rabbit (4)
Images
  1. 1 image (2)
  2. 3+ images (2)
Images: Applications
  1. Immunofluorescence (IF) (2)
  2. Western blot / Immunoblot (WB) (2)
  3. IHC (1)
  4. Immunoprecipitation (IP) (1)
Manufacturer
  1. OriGene Technologies (4)
Service
  • OriGene Technologies GmbH
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  • D-32052 Herford
  • Germany
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  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
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