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CACNA1E antibody

Principal name

CACNA1E antibody

Alternative names for CACNA1E antibody

CACH6, CACNL1A6, Cav2.3, Brain calcium channel II, Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha

SwissProt ID

Q07652 (Rat), Q15878 (Human), Q61290 (Mouse)

Gene ID

777 (CACNA1E), 54234 (Cacna1e)

Ncbi ID

9606, NP_000712.2, NP_000712, 10116, NM_000721

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CACNA1E antibody

Voltage-dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.The voltage dependent Ca2+ channels are composed of several subunits; a1, Ã?, a2d and ?. Cav channels were origilly divided into six physiological types: L, N , P, Q, R, and T type.The Cav2.3 (formerly med a1E) protein, forms the R type channels. R-type channels are highly sensitive to both SNX-482 (#RTS-500) and NiCl2. Cav2.3 channels were shown to mediate fast excitatory transmission in several sypses including the hippocampus.Cav2.3 channels can be modulated by the muscarinic G-protein coupled receptors. In HEK-293 cells, expressing Cav2.3 channels, the R-type channel was shown to be both facilitated and inhibited by m1 and m2 muscarinic receptors. However, inhibition was much weaker than facilitation for the m1 receptor, while for m2 receptors, inhibition was much more pronounced than activation.Facilitation and inhibition by the same receptors was probably exerted via different pathways as was indicated by their response to various inhibitors.

Western blot analysis of Cav2.3 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.

Western blot analysis of rat brain membranes: 1. Anti-CaV2.3 antibody, (1:200). 2. Anti-CaV2.3 antibody, preincubated with the control peptide antigen.

TA328726

Expression of Cav2.3 in mouse cerebellum. Immunohistochemical staining of mouse cerebellum with Anti-Cav2.3 antibody. Cav2.3 (red) appears in both soma and dendritic trees of several Purkinje cells. Staining of neurofilament 200 (green) in the same brain section demonstrates the relationship between axons passing through the granule layer and the Purkinje cells.

TA328726

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

TA351021

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using (CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

TA351021

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA328726	CACNA1E antibody
	Rabbit Polyclonal Anti-CaV2.3
	Rabbit		Purified	Hu, Ms, Rt	WB	0.2 ml / €585.00
						OriGene Technologies, Inc.
+1 additional image
TA351021	CACNA1E antibody
	Rabbit Polyclonal Anti-CACNA1E Antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image
AP05133PU-N	CACNA1E antibody
	Rabbit	IgG	Purified	Hu, Rt	WB	0.1 mg / €400.00
						OriGene Technologies GmbH

Human Lenti ORF Particles

Catalog No.
RC221733L1V	Lenti ORF particles, CACNA1E (Myc-DDK tagged) - Human calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), transcript variant 3, 200 uL, >10^7 TU/mL
		200 µl / €2,420.00
		OriGene Technologies, Inc.

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