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CACNA2D2 antibody

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Principal name

CACNA2D2 antibody

Alternative names for CACNA2D2 antibody

KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2

SwissProt ID

Q6PHS9 (Mouse), Q8CFG6 (Rat), Q9NY47 (Human)

Gene ID

9254 (CACNA2D2), 300992 (Cacna2d2), 56808

Ncbi ID

9606, 10116, NP_001005505, NM_001174051, NP_001167522, NP_001005505.1, NP_783182.1, NP_001167518.1, NM_001174047, NM_001174048, NM_001174049, NM_001174050, NM_175592, NM_001005505, NM_006030

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CACNA2D2 antibody

Voltage-gated Ca2+ channels (CaV), eble the passage of Ca2+ ions in a voltage dependent manner. These heteromeric entities are formed in part by the pore-forming a1 subunit which determines the biophysical and pharmacological properties of the channel.CaV1 and CaV2 channels are high-voltage activated (HVA) CaV channels. The a1 subunit of these channels normally interacts and associates with a2d subunit, a membrane anchored protein and CaVÃ?, a cytosolic protein.Four a2d subunits have been cloned to date: a2d1- 4. This subunit origites from a single gene. The corresponding protein is modified by post-translatiol cleavage yielding a a2 subunit which is disulfide bonded to the d subunit. All a2d subunits are GPI- (glycosylphosphatidylinositol) anchored proteins3. The role of this subunit is important for the membrane trafficking of the a1 subunit, and also has a role in influencing the biophysical properties of the channel.a2d can be expressed as various splice variants and expressed in a tissue specific manner. a2d2 can be detected in the brain, heart, lung, spleen and liver.Gabapentin and pregabalin are two commonly used anti-epileptic drugs. They act on CaV channels via the a2d1 and a2d2 subunits by disturbing their membrane trafficking, thereby decreasing Ca2+ currents.

H00009254-M12 - CACNA2D2
CACNA2D2 monoclonal antibody (M12), clone 4E3. Western Blot analysis of CACNA2D2 expression in HeLa(Cat # L013V1 ).
AM31742PU-N - CACNA2D2
Human Kidney, Tubules: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM31742PU-N - CACNA2D2
Detection limit for recombinant GST tagged CACNA2D2 is 0.3 ng/ml as a capture antibody.
TP330662 - CACNA2D2
TA324518 - CACNA2D2
CACNA2D2 Antibody (Center) (Cat. #TA324518) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow).
TA324518 - CACNA2D2
CACNA2D2 Antibody (Center) (Cat. #TA324518)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CACNA2D2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
TA324518 - CACNA2D2
IF image of U251 cell stained with CACNA2D2 Antibody (Center)(Cat#TA324518).U251 cells were incubated with CACNA2D2 primary antibody (1:25, 1 h at 37?). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7 units/ml).CACNA2D2 immunoreactivity is localized to Cytoplasm significantly.
TA328760 - CACNA2D2
Western blot analysis of rat lung (lanes 1 and 6), rat brain (lanes 2 and 7), Mouse brain (lanes 3 and 8), rat heart (lanes 4 and 9) and mouse heart (lanes 5 and 10) lysates: 1-5. Anti- Cava2d2 (extracellular) antibody, (1:200). 6-10. Anti- Cava2d2 (extracellular) antibody, preincubated with the control peptide antigen.
TA328760 - CACNA2D2
Expression of Cava2d2 in rat cerebellum. Immunohistochemical staining rat cerebellum using Anti- Cava2d2 (extracellular) antibody. A. Cava2d2 (green) appears in the soma of purkinje cells (arrow) and in the molecular layer (M). B. Pre-incubation of the antibody with the control peptide antigen blocks staining of Purkinje cells and molecular layer. DAPI is used as the counterstain (blue).
TA338138 - CACNA2D2
WB Suggested Anti-CACNA2D2 Antibody; Titration: 1.0 ug/ml; Positive Control: HCT15 Whole Cell
CPA9253-100ul - CACNA2D2
Western blot analysis of CACNA2D2 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates.
CPA9253-100ul - CACNA2D2
Immunohistochemical analysis of CACNA2D2 staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CACNA2D2 antibody
  Rabbit polyclonal CACNA2D2 Antibody (Center)  
CACNA2D2 Antibody (Center) (Cat. #TA324518) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow). Rabbit IgG Purified Ms ICC/IF, P, WB
0.4 ml / €415.00
  OriGene Technologies, Inc.
+2 additional images

CACNA2D2 antibody
  Rabbit Polyclonal Anti-CaV alpha2delta2 (extracellular)  
Western blot analysis of rat lung (lanes 1 and 6), rat brain (lanes 2 and 7), Mouse brain (lanes 3 and 8), rat heart (lanes 4 and 9) and mouse heart (lanes 5 and 10) lysates: 1-5. Anti- Cava2d2 (extracellular) antibody, (1:200). 6-10. Anti- Cava2d2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+1 additional image

CACNA2D2 (65-163) antibody
Human Kidney, Tubules: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3A4 Purified Hu E, P, WB
50 µg / €475.00
  OriGene Technologies GmbH
+1 additional image

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CACNA2D2 (transcript variant 3)
  Recombinant protein of human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3.  
CACNA2D2 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €788.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CACNA2D2 overexpression lysate
CACNA2D2 overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,410.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (mGFP-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,410.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, CACNA2D2 (mGFP-tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (mGFP-tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,420.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,180.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,180.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, CACNA2D2 (Myc-DDK tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3 , 200 uL, >10^7 TU/mL
Lenti ORF particles, CACNA2D2 (Myc-DDK tagged) - Human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €2,190.00
  OriGene Technologies, Inc.
 

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cacna2d2 (GFP-tagged) - Mouse calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cacna2d2 (GFP-tagged) - Mouse calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,890.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cacna2d2 (Myc-DDK-tagged) - Mouse calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, Cacna2d2 (Myc-DDK-tagged) - Mouse calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cacna2d2 (GFP-tagged ORF) - Rat calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Cacna2d2 (GFP-tagged ORF) - Rat calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), 200 uL, >10^7 TU/mL  
200 µl / €2,520.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cacna2d2 (Myc-DDK-tagged ORF) - Rat calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Cacna2d2 (Myc-DDK-tagged ORF) - Rat calcium channel, voltage-dependent, alpha 2/delta subunit 2 (Cacna2d2), 200 uL, >10^7 TU/mL  
200 µl / €2,270.00
  OriGene Technologies, Inc.
 

15 Item(s)

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15 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. Human Lenti ORF Particle (6)
  2. Lysate (1)
  3. Mouse Lenti ORF Particle (2)
  4. Primary Antibody (3)
  5. Protein | Growth Factor (1)
  6. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (2)
  2. Monoclonal (1)
Target
  1. CACNA2D2 (4)
Property
  1. 65-163 (1)
Reactivity
  1. Human (Hu) (2)
  2. Mouse (Ms) (2)
  3. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Paraffin Sections (P) (2)
  3. Enzyme Immunoassay (E) (1)
  4. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
Presentation
  1. Purified (3)
Host
  1. Rabbit (2)
  2. Mouse (1)
Images
  1. 1 image (4)
  2. 3+ images (1)
Images: Applications
  1. IHC (2)
  2. Western blot / Immunoblot (WB) (2)
  3. ELISA (capture) (E(capture)) (1)
  4. Immunofluorescence (IF) (1)
  5. Paraffin Sections (P) (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (15)
Service
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