CACNA2D3 antibody

Background of CACNA2D3 antibody

Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. On the basis of their voltage activation properties, CaV channels can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels. HVA channels are heteromultimers composed of four independently encoded proteins, the pore-forming a1 subunit, which triggers Ca2+ flow across the membrane, and the auxiliary subunits a2d, ?, and Ã?. The Ca2+ channel a2d subunit is a heavily glycosylated protein that is encoded by a single gene and post-translatiolly cleaved to yield a2 and d subunits linked by a disulfide bond with a single transmembrane segment.The a2d subunit regulates many functiol aspects of Ca2+ channels, such as gating, regulating voltage dependent kinetics, and increasing functiol channel density on the plasma membrane.There are four proteins that comprise CaVa2d: CaVa2d1, CaVa2d2, CaVa2d3 and CaVa2d46. The CaVa2d3 subunit is predomintly expressed in neurol tissue. The CaVa2d3 subunit regulates all classes of HVA calcium channels. The Caa2d3 subunits in the nerve termil function in syptic morphogenesis and cytoskeletal organization, and that this role is independent of their function in a1 subunit localization and physiology.CaVa2d3 is likely to be the primary presyptic a2d isoform mediating morphological development of the neuromuscular junction (NMJ), since alleles have such a large effect on NMJ development and abolish all action-potential evoked transmission. Recent study shows that methylation-dependent transcriptiol silencing of CaVa2d3 may contribute to the metastatic phenotype of breast cancer.