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CAMLG antibody

Principal name

CAMLG antibody

Alternative names for CAMLG antibody

CAML, Calcium signal-modulating cyclophilin ligand

SwissProt ID

P49069 (Human), P49070 (Mouse)

Gene ID

819 (CAMLG), 12328 (Caml)

Ncbi ID

9606, NP_001736, NP_001736.1, NP_031622.2, NM_007596, NM_001745

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CAMLG antibody

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

General readings

Nagano,J., (2005) Biochem. Biophys. Res. Commun. 338 (2), 880-889

CAMLG polyclonal antibody (A01), Lot # 060717JCS1 Western Blot analysis of CAMLG expression in 293 ( Cat # L026V1 ).

H00000819-A01

Detection limit for recombinant GST tagged CAMLG is approximately 1ng/ml as a capture antibody.

H00000819-M02

CAMLG MaxPab polyclonal antibody. Western Blot analysis of CAMLG expression in rat brain.

H00000819-B01P

Western Blot analysis of CAMLG expression in transfected 293T cell line (H00000819-T01) by CAMLG MaxPab polyclonal antibody.Lane 1: CAMLG transfected lysate(32.56 KDa).Lane 2: Non-transfected lysate.

H00000819-B01P

CAMLG MaxPab polyclonal antibody. Western Blot analysis of CAMLG expression in A-431.

H00000819-B01P

CAMLG MaxPab rabbit polyclonal antibody. Western Blot analysis of CAMLG expression in human spleen.

H00000819-D01P

Western Blot analysis of CAMLG expression in transfected 293T cell line (H00000819-T01) by CAMLG MaxPab polyclonal antibody.Lane 1: CAMLG transfected lysate(33.00 KDa).Lane 2: Non-transfected lysate.

H00000819-D01P

CAMLG MaxPab rabbit polyclonal antibody. Western Blot analysis of CAMLG expression in HepG2.

H00000819-D01P

Human Liver; WB Suggested Anti-CAMLG Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Human Liver; CAMLG antibody - N-terminal region (ARP48191_P050) in Human Liver cells using Western Blot

ARP48191_P050

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-CAMLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504329)

TA504329

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-CAMLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504329)

TA504329

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CAMLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504329)

TA504329

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CAMLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504329)

TA504329

Anti-CAMLG mouse monoclonal antibody (TA504329) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CAMLG(RC218292).

TA504329

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CAMLG (RC218292, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CAMLG.

TA504329

HEK293T cells transfected with either RC218292 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-CAMLG antibody(TA504329), and then analyzed by flow cytometry.

TA504329

Anti-CAMLG mouse monoclonal antibody (TA504363) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CAMLG(RC218292).

TA504363

TA504363

HEK293T cells transfected with either RC218292 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-CAMLG antibody(TA504363), and then analyzed by flow cytometry.

TA504363

Flow cytometric Analysis of Jurkat cells, using anti-CAMLG antibody(TA504363),(Red), compared to a nonspecific negative control antibody,(Blue).

TA504363

Anti-CAMLG mouse monoclonal antibody (TA504636) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CAMLG(RC218292).

TA504636

TA504636

HEK293T cells transfected with either RC218292 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-CAMLG antibody(TA504636), and then analyzed by flow cytometry.

TA504636

TP318292

Primary Antibodies

Catalog No.	Host	Iso.	Clone	Pres.	React.	Applications
TA504329	CAMLG antibody
	CAMLG mouse monoclonal antibody, clone OTI1A3 (formerly 1A3)
	Mouse	IgG1	OTI1A3	Purified	Hu	F, ICC/IF, P, WB	0.1 ml / €379.00
							OriGene Technologies, Inc.
+6 additional images	Highly validated antibody!
TA504363	CAMLG antibody
	CAMLG mouse monoclonal antibody, clone OTI2H3 (formerly 2H3)
	Mouse	IgG1	OTI2H3	Purified	Hu	F, ICC/IF, WB	0.1 ml / €360.00
							OriGene Technologies, Inc.
+3 additional images	Highly validated antibody!
TA504636	CAMLG antibody
	CAMLG mouse monoclonal antibody, clone OTI1H3 (formerly 1H3)
	Mouse	IgG2b	OTI1H3	Purified	Hu	F, ICC/IF, WB	0.1 ml / €360.00
							OriGene Technologies, Inc.
+2 additional images

Proteins & Growth Factors

Catalog No.	Species	Purity	Source
TP318292	CAMLG
	Recombinant protein of human calcium modulating ligand (CAMLG)
	Human	> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
				OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.
MR204041L2V	Lenti ORF particles, Caml (GFP-tagged) - Mouse calcium modulating ligand (Caml), 200 uL, >10^7 TU/mL
		200 µl / €930.00
		OriGene Technologies, Inc.

MR204041L1V	Lenti ORF particles, Caml (Myc-DDK-tagged) - Mouse calcium modulating ligand (Caml), 200 uL, >10^7 TU/mL
		200 µl / €830.00
		OriGene Technologies, Inc.

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