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CASK antibody

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Principal name

CASK antibody

Alternative names for CASK antibody

Lin-2 homolog, LIN2, Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase

SwissProt ID

O14936 (Human), O70589 (Mouse), Q62915 (Rat)

Gene ID

29647 (Cask), 8573 (CASK), 12361

Ncbi ID

NP_071520.1, 9606, NP_003679, ADR83272.1, NM_003688, NP_001119526.1, NP_033936.2, NM_009806, NM_022184, NM_001126055, NM_001126054

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CASK antibody

CASK (calmodulin sensitive kinase) is a ~112kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures (1). While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator.
Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.

General readings

Dimitratos SD, Woods DF, and Bryant PJ. Camguk, Lin-2, and CASK: novel membrane associated guanylate kinase homologs that also contain CaM kinase domains. Mech. Dev. 1997; 63:127-30.

PAB2776 - CASK
Formalin-fixed and paraffin-embedded human cancer tissue reacted with CASK polyclonal antibody ( Cat # PAB2776 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
PAB2776 - CASK
Western blot analysis of CASK polyclonal antibody ( Cat # PAB2776 ) in mouse kidney lysate. CASK ( arrow ) was detected using purified polyclonal. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
AP55443CP-N - CASK
Western blot analysis in mouse brain tissue lysate with CASK antibody Cat.-No. AP55443PU-Nat 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
TP320531 - CASK
73-000 - CASK
Adult rat brain immunohistochemistry
73-000 - CASK
Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from humancerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K56A/50 (left) or N52A/42 (right) TC supe.
73-000 - CASK
adult rat brain membrane immunoblot
75-000 - CASK
Adult rat brain immunohistochemistry
75-000 - CASK
Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from humancerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K56A/50 (left) or N52A/42 (right) TC supe.
75-000 - CASK
adult rat brain membrane immunoblot
TA302217 - CASK
Western blot analysis of CASK (arrow) using Cask Antibody (C-term) (Cat.#TA302217). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CASK gene (Lane 2) (Origene Technologies).
TA302217 - CASK
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
TA325180 - CASK
Rat Cask Antibody (Center) (Cat. #TA325180) western blot analysis in rat brain tissue lysates (35ug/lane).This demonstrates the Rat Cask antibody detected the Rat Cask protein (arrow).
TA326522 - CASK
Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody
TA326522 - CASK
IHC analysis of CASK in frozen sections of mouse brain extract using the antibody
TA326628 - CASK
Western blot analysis of CASK in mouse brain tissue lysate with CASK antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
TA326628 - CASK
Immunofluorescence of CASK in human brain tissue with CASK antibody at 20 ug/mL.
TA332527 - CASK
Western blot analysis of extracts of various cell lines, using CASK antibody.
TA332527 - CASK
Immunohistochemistry of paraffin-embedded human esophageal cancer using CASK antibody at dilution of 1:100 (400x lens).
TA332527 - CASK
Immunohistochemistry of paraffin-embedded rat brain using CASK antibody at dilution of 1:100 (400x lens).
TA332527 - CASK
Immunohistochemistry of paraffin-embedded rat kidney using CASK antibody at dilution of 1:100 (400x lens).
TA332527 - CASK
Immunohistochemistry of paraffin-embedded rat lung using CASK antibody at dilution of 1:100 (400x lens).
TA332527 - CASK
Immunofluorescence analysis of U2OS cell using CASK antibody. Blue: DAPI for nuclear staining.
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  2. Highly Validated (1)

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CASK antibody
  Rabbit anti-CASK Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CASK antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €335.00
  OriGene Technologies, Inc.
+5 additional images

Highly validated antibody!

CASK (C-term) antibody
  Rabbit Polyclonal Antibody against CASK (C-term)  
Western blot analysis of CASK (arrow) using Cask Antibody (C-term) (Cat.#TA302217). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CASK gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €415.00
  OriGene Technologies, Inc.
+1 additional image

CASK antibody
  Rabbit polyclonal Rat Cask Antibody (Center)  
Rat Cask Antibody (Center) (Cat. #TA325180) western blot analysis in rat brain tissue lysates (35ug/lane).This demonstrates the Rat Cask antibody detected the Rat Cask protein (arrow). Rabbit IgG Purified Hu, Ms, Rt WB
0.4 ml / €415.00
  OriGene Technologies, Inc.

CASK antibody
  Mouse Monoclonal Anti-CASK Antibody  
Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S56A-50 Purified Hu, Ms, Rt, Xen, Ze WB
0.1 mg / €410.00
  OriGene Technologies, Inc.
+1 additional image

CASK (N-term) antibody
  Rabbit Polyclonal CASK Antibody  
Western blot analysis of CASK in mouse brain tissue lysate with CASK antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €415.00
  OriGene Technologies, Inc.
+1 additional image

CASK antibody
Adult rat brain immunohistochemistry Mouse IgG1 K56A/50 Supernatant Hu, Ms, Rt, Xen, Ze C, IP, WB
5 ml / €490.00
  Antibodies Incorporated
+2 additional images

NeuroMab

CASK antibody
Adult rat brain immunohistochemistry Mouse IgG1 K56A/50 Purified Hu, Ms, Rt, Xen, Ze C, IP, WB
0.1 ml / €570.00
  Antibodies Incorporated
+2 additional images

NeuroMab

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CASK (transcript variant 1)
  Recombinant protein of human calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1  
CASK Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €788.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CASK overexpression lysate
CASK overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CASK (mGFP-tagged)-Human calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, CASK (mGFP-tagged)-Human calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,040.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cask (GFP-tagged ORF) - Rat calcium/calmodulin-dependent serine protein kinase (MAGUK family) (Cask), 200 uL, >10^7 TU/mL
Lenti ORF particles, Cask (GFP-tagged ORF) - Rat calcium/calmodulin-dependent serine protein kinase (MAGUK family) (Cask), 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Cask (Myc-DDK-tagged ORF) - Rat calcium/calmodulin-dependent serine protein kinase (MAGUK family) (Cask), 200 uL, >10^7 TU/mL
Lenti ORF particles, Cask (Myc-DDK-tagged ORF) - Rat calcium/calmodulin-dependent serine protein kinase (MAGUK family) (Cask), 200 uL, >10^7 TU/mL  
200 µl / €1,580.00
  OriGene Technologies, Inc.
 

12 Item(s)

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12 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. Human Lenti ORF Particle (1)
  2. Lysate (1)
  3. Primary Antibody (7)
  4. Protein | Growth Factor (1)
  5. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (4)
  2. Monoclonal (3)
Target
  1. CASK (8)
Property
  1. C-term (1)
  2. N-term (1)
Reactivity
  1. Human (Hu) (7)
  2. Mouse (Ms) (7)
  3. Rat (Rt) (6)
  4. Xenopus (Xen) (3)
  5. Zebrafish (Ze) (3)
Applications
  1. Western blot / Immunoblot (WB) (6)
  2. Frozen sections (C) (2)
  3. Immunoprecipitation (IP) (2)
  4. Enzyme Immunoassay (E) (1)
  5. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
  6. Paraffin Sections (P) (1)
Presentation
  1. Purified (5)
  2. Aff - Purified (1)
  3. Supernatant (1)
Host
  1. Rabbit (4)
  2. Mouse (3)
Images
  1. 1 image (8)
  2. 3+ images (3)
  3. 5+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (5)
  2. IHC (3)
  3. Frozen sections (C) (2)
  4. Immunofluorescence (IF) (2)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (10)
  2. Antibodies Incorporated (2)
Service
  • OriGene Technologies GmbH
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  • Germany
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  • free call: 0800-227 47 46 (Germany only)
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