CD126 / IL6R antibody
Principal name
CD126 / IL6R antibody
Alternative names for CD126 / IL6R antibody
Interleukin-6 receptor subunit alpha, IL-6R-alpha, IL-6R 1, IL6 Receptor alpha, Membrane glycoprotein 80
Ncbi ID
9606, NP_034689.2, NP_000556, NP_034689, NP_000556.1, NM_181359, NP_852004, NM_000565
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C), Functional assay (FN), ELISA (capture) (E(capture)), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of CD126 / IL6R antibody
IL6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL6 binding receptor protein (IL6R) and a 130 kDa signal transducing protein consisting of a 19 amino acid residue signal peptide (gp130). Human IL6R is a 468 amino acid residue type I membrane protein consisting of a 19 amino acid residue signal peptide, a 339 residue extracellular region, a 28 residue transmembrane region and an 82 residue cytoplasmic region. The ectodomain of IL6R is made up of an immunoglobulin like domain and a cytokine receptor superfamily domain. A naturally occurring soluble form of the IL6R, which binds IL6 and which mediates IL6 signaling through interaction with gp130, is identified in the urine of healthy adult humans. It has also been detected in human and mouse serum as well as in the conditioned medium of various cells including human peripheral blood mononuclear cells, and several T cell or granulocyte/macrophage cell lines. Increased expression of the c-fos and c-myc protooncogenes have been linked to IL6 receptor activation.
General readings
1. Clement C. et al, CR.3.2 Leucocyte Typing V, Boston, 1993
Kube D. et al., Blood, 2001; 98 : 762 - 770
2. Labbozzetta, M. et al.,Ann N Y Acad Sci.,2006; 1089: 268-75.
3. Lebeau, B. et al., FEBS Lett.,1997; 407(2): 141-7.
4. Mouthon, M. A. et al., Blood,1994; 84(4): 1085-97.
5. Muller-Newen, G. et al., Eur J Biochem.,1996; 236(3): 837-42.
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Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA327080 | CD126 / IL6R antibody |
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| Rabbit anti-IL-6R Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.1 mg /
€335.00
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| OriGene Technologies, Inc. | |||||||
| TA506855 | CD126 / IL6R antibody |
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| IL6R mouse monoclonal antibody, clone OTI1B5 (formerly 1B5) | |||||||
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Mouse | IgG2a | OTI1B5 | Purified | Hu | WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
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| TA506859 | CD126 / IL6R antibody |
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| IL6R mouse monoclonal antibody, clone OTI2F4 (formerly 2F4) | |||||||
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Mouse | IgG1 | OTI2F4 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
|
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| AM31172AF-N | CD126 / IL6R antibody |
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Mouse | IgG1 | B-F19 | Azide Free | Hu | F, FN |
0.2 mg /
€350.00
|
| OriGene Technologies GmbH | |||||||
| AM31173AF-N | CD126 / IL6R antibody |
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 |
Mouse | IgG1 | B-N12 | Azide Free | Hu | E, F |
0.2 mg /
€350.00
|
| OriGene Technologies GmbH | |||||||
| AM31173FC-N | CD126 / IL6R antibody |
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Mouse | IgG1 | B-N12 | FITC | Hu | E, F |
1ml (100T) /
€350.00
|
| OriGene Technologies GmbH | |||||||
| AM31357AF-N | CD126 / IL6R antibody |
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Mouse | IgG1 | B-R6 | Azide Free | Hu | C, F, FN, IP |
0.2 mg /
€350.00
|
| OriGene Technologies GmbH | |||||||
| AM31357FC-N | CD126 / IL6R antibody |
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Mouse | IgG1 | B-R6 | FITC | Hu | F |
1ml (100T) /
€350.00
|
| OriGene Technologies GmbH | |||||||
| AM31357PU-N | CD126 / IL6R antibody |
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|
Mouse | IgG1 | B-R6 | Purified | Hu | C, F |
2ml (200T) /
€320.00
|
| OriGene Technologies GmbH | |||||||
| AP31764PU-N | CD126 / IL6R antibody |
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Rabbit | IgG | Aff - Purified | Hu | E, P, WB |
50 µl /
€425.00
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|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
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| DM3568P | CD126 / IL6R (Extracell. Dom.) antibody |
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Rat | IgG2 | 14F33 | Purified | Ms | C, WB |
0.1 mg /
€460.00
|
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP319601 | CD126 / IL6R (transcript variant 2) |
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| Recombinant protein of human interleukin 6 receptor (IL6R), transcript variant 2 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP321874 | CD126 / IL6R (transcript variant 1) |
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| Recombinant protein of human interleukin 6 receptor (IL6R), transcript variant 1 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP723414 | CD126 / IL6R (transcript variant 2) |
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| Purified recombinant protein of Human interleukin 6 receptor (IL6R), transcript variant 2. | |||||
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Human | > 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€135.00
|
|
| OriGene Technologies, Inc. | |||||
ELISA Kits
| Catalog No. | ||
|---|---|---|
| EA101155 | Human CD126 ELISA Kit |
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1 kit /
€425.00
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|
| OriGene Technologies, Inc. | ||
| EA101156 | Human CD126 ELISA Kit |
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1 kit /
€645.00
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| OriGene Technologies, Inc. | ||
| EA100489 | Human IL-6R alpha ELISA Kit |
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1 kit /
€500.00
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|
| OriGene Technologies, Inc. |
Lysates
| Catalog No. | ||
|---|---|---|
| LY405751 | IL6R overexpression lysate |
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0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
