CD56 antibody
Principal name
CD56 antibody
Alternative names for CD56 antibody
NCAM-1, N-CAM-1, NCAM, Neural cell adhesion molecule 1
Ncbi ID
NP_000606, NP_000606.3, NP_004235, NP_113709, 9606, 10116, NM_000615.5, NP_001074914.1, NP_851996, NM_181351, NM_001081445, BC011310, NM_001113204, NM_031521, NM_010875
Available reactivities
Available hosts
Available applications
Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Functional assay (FN), ELISA (detection) (E(detection))
Background of CD56 antibody
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
NCAM can be found in central and peripheral nerve cells, neuroendocrine tissues and at the surface of NK-cells. Also, NCAM is present in malignancies derived from these tissues and cells.
General readings
1. Lanier LL, Chang C, Azuma M, Ruitenberg JJ, Hemperly JJ, Phillips JH: Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). J Immunol. 1991 Jun 15;146(12):4421-6.
2. Jakovcevski I, Mo Z, Zecevic N: Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. Neuroscience. 2007 Oct 26;149(2):328-37.
3. Ohishi Y, Kaku T, Oya M, Kobayashi H, Wake N, Tsuneyoshi M: CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls. Gynecol Oncol. 2007 Oct;107(1):30-8.
4. McCluggage WG, McKenna M, McBride HA: CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2007 Jul;26(3):322-7.
5. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
6. Leukocyte Typing VII., Mason D. et al. (Eds.), Oxford University Press (2002).
7. Lin CW, Liu TY, Chen SU, Wang KT, Medeiros LJ, Hsu SM: CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. Blood. 2005 Nov 15;106(10):3567-74.
8. Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med. 2003 Nov 17;198(10):1453-62.
9. Drbal K, Moertelmaier M, Holzhauser C, Muhammad A, Fuertbauer E, Howorka S, Hinterberger M, Stockinger H, Schütz GJ: Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement. Int Immunol. 2007 May;19(5):675-84.
10. Brdicka T, Imrich M, Angelisová P, Brdicková N, Horváth O, Spicka J, Hilgert I, Lusková P, Dráber P, Novák P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsí V: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002 Dec 16;196(12):1617-26.
11. Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, Sollid LM, Lundin KE: Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.
12. Yates J, Rovis F, Mitchell P, Afzali B, Tsang JY, Garin M, Lechler RI, Lombardi G, Garden OA: The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol. 2007 Jun;19(6):785-99.
13. Hovden AO, Karlsen M, Jonsson R, Aarstad HJ, Appel S: Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 2011 Jan 5;12:2.
14. Kanderova V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, Hrusak O, Lund-Johansen F, Kalina T: High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016 Apr;15(4):1246-61.





Immunostaining of the neural cell adhesion molecule (NCAM) in small cell lung cancer cell line NCI-H82























































- Quick-Filters:
- Highly Validated (11)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| UM500067 | CD56 (transcript variant 2) antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB83 | |||||||
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Mouse | IgG1 | UMAB83 | Purified | Hu | P |
0.1 ml /
€468.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
Highly validated antibody! |
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| UM570067 | CD56 (transcript variant 2) antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB83 | |||||||
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Mouse | IgG1 | UMAB83 | Purified | Hu | P |
30 µl /
€180.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
Highly validated antibody! |
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| UM800084 | CD56 antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB192 | |||||||
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Mouse | IgG2b | UMAB192 | Purified | Hu | P |
0.1 ml /
€468.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| UM800086 | CD56 (transcript variant 2) antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB194 | |||||||
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Mouse | IgG1 | UMAB194 | Purified | Hu | P |
0.1 ml /
€468.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| UM870084 | CD56 (transcript variant 2) antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB192 | |||||||
![]() |
Mouse | IgG2b | UMAB192 | Purified | Hu | P |
30 µl /
€180.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
||||||
| UM870086 | CD56 (transcript variant 2) antibody |
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| NCAM1/CD56 mouse monoclonal antibody,clone UMAB194 | |||||||
![]() |
Mouse | IgG1 | UMAB194 | Purified | Hu | P |
30 µl /
€180.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| TA804951 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI1A3 (formerly 1A3) | |||||||
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Mouse | IgG1 | OTI1A3 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA804952 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7) | |||||||
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Mouse | IgG2a | OTI1C7 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA804954 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI2A2 (formerly 2A2) | |||||||
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Mouse | IgG1 | OTI2A2 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA805182 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI3H2 (formerly 3H2) | |||||||
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Mouse | IgG1 | OTI3H2 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA805376 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI1B9 (formerly 1B9) | |||||||
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Mouse | IgG2b | OTI1B9 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| AM33261PU-S | CD56 antibody |
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Mouse | IgG1 | SPM128 | Purified | Hu, Rt, Ze | C, F, ICC/IF, IP, P, WB |
0.1 mg /
€430.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
OriGene recommends this product for Immunohistochemistry. |
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| AM33261PU-T | CD56 antibody |
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Mouse | IgG1 | SPM128 | Purified | Hu, Rt, Ze | C, F, ICC/IF, IP, P, WB |
20 µg /
€240.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
OriGene recommends this product for Immunohistochemistry. |
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| AM50146PU-S | CD56 antibody |
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Mouse | IgG1 | SPM489 | Purified | Hu | C, F, ICC/IF, IP, P, WB |
0.1 mg /
€430.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
OriGene recommends this product for Immunohistochemistry. |
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| AM50146PU-T | CD56 antibody |
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![]() |
Mouse | IgG1 | SPM489 | Purified | Hu | C, F, ICC/IF, IP, P, WB |
20 µg /
€240.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
OriGene recommends this product for Immunohistochemistry. |
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| TA323611 | CD56 antibody |
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| Anti-NCAM1 (CD56) Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA327645 | CD56 antibody |
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| Mouse Monoclonal NCAM1 (CD56) Antibody | |||||||
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Mouse | IgG1 | 123C3.D5 | Purified | Hu | P |
1 ml /
€435.00
|
| OriGene Technologies, Inc. | |||||||
| TA327646 | CD56 antibody |
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| Rabbit Monoclonal NCAM1 (CD56) Antibody | |||||||
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Rabbit | IgG1 | MRQ-42 | Purified | Hu | P |
1 ml /
€435.00
|
| OriGene Technologies, Inc. | |||||||
| TA506208 | CD56 antibody |
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| NCAM1 (CD56) mouse monoclonal antibody, clone OTI1G4 (formerly 1G4) | |||||||
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Mouse | IgG1 | OTI1G4 | Purified | Can, Hu, Mky, Ms, Rt | P, WB |
0.1 ml /
€379.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA506223 | CD56 antibody |
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| NCAM1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4) | |||||||
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Mouse | IgG1 | OTI2D4 | Purified | Hu | WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||













































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