CDC25A antibody
Principal name
CDC25A antibody
Alternative names for CDC25A antibody
CDC-25A, M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A, Cell Division Cycle 25A
Available reactivities
Available hosts
Available applications
Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Dot blot (Dot), ELISA (detection) (E(detection))
Background of CDC25A antibody
The cdc25 protein phosphatase family plays a critical role in activating cyclin-dependent kises (CDKs) via dephosphorylation of conserved Thr14/Tyr15 inhibitory phosphorylation sites. While cdc25C is primarily responsible for activating CDK1 to overcome the G2/M checkpoint and allow mitotic entry, the primary substrate of cdc25A is CDK2, which, when active, allows progression through the G1/S and intra-S checkpoints. Abundance, subcellular localization and activity of cdc25A is tightly controlled by a variety of mechanisms, including phosphorylation, ubiquitition, and inhibitory binding to 14-3-3 proteins. During normal cell cycle progression, elevated c-Myc and E2F transcription factor levels lead to increased cdc25A expression. When conditions are favorable for D synthesis, cdc25A and CDK2 form an activation loop, wherein each activates the other enzyme. D damage, on the other hand, leads to multisite phosphorylation at inhibitory sites (Ser123, Ser177, Ser278, Ser292, and Thr506) by Chk1 and Chk2, which result in 14-3-3 binding and ubiquitin-mediated degradation.
General readings
1. Min W et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun 4:2993 (2013).
2. Giessrigl B et al. Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Hum Mol Genet 21:4615-27 (2012).
3. Vo NT et al. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis 31:2074-81 (2010). WB ; Human .













































































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA590333 | CDC25A antibody |
||||||
| Rabbit Polyclonal Cdc25A Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 mg /
€409.00
|
|
| OriGene Technologies, Inc. | |||||||
+8 additional images |
Highly validated antibody! |
||||||
| TA309985 | CDC25A antibody |
||||||
| Rabbit anti-cdc25A (Phospho-Ser75) polyclonal antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€355.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA310044 | CDC25A antibody |
||||||
| Rabbit anti-CDC25A polyclonal antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€450.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313586 | CDC25A antibody |
||||||
| Rabbit polyclonal CDC25A (Ab-178) antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA313588 | CDC25A antibody |
||||||
| Rabbit polyclonal CDC25A (Ser75) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | E, P, WB |
0.1 ml /
€335.00
|
||
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA313589 | CDC25A antibody |
||||||
| Rabbit polyclonal CDC25A (Thr507) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA313590 | CDC25A antibody |
||||||
| Rabbit polyclonal CDC25A (Ser82) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313593 | CDC25A antibody |
||||||
| Rabbit polyclonal CDC25A (Ser178) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA323117 | CDC25A antibody |
||||||
| Anti-CDC25A Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA323118 | CDC25A antibody |
||||||
| Anti-CDC25A Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325324 | CDC25A antibody |
||||||
| Rabbit Polyclonal CDC25A Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325328 | CDC25A antibody |
||||||
| Rabbit Polyclonal CDC25A (Ser75) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA326970 | CDC25A antibody |
||||||
| CDC25A Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA327804 | CDC25A antibody |
||||||
| Rabbit Polyclonal Phospho-CDC25A (Thr507) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA332746 | CDC25A antibody |
||||||
| Rabbit anti-CDC25A Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
|
||
| OriGene Technologies, Inc. | |||||||
| TA333175 | CDC25A antibody |
||||||
| phospho-CDC25A-S76 Rabbit Polyclonal Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
|
||
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA348450 | CDC25A antibody |
||||||
| Rabbit Polyclonal Anti-Phospho-CDC25A(Ser75) Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA350822 | CDC25A antibody |
||||||
| Rabbit Polyclonal Anti-CDC25A Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AM05219AF-N | CDC25A antibody |
||||||
![]() |
Mouse | IgG2a | DCS-121 | Azide Free | Hu, Ms, Rt | IP, P, WB |
0.1 mg /
€355.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
|||||||
| AM05219PU-N | CDC25A antibody |
||||||
![]() |
Mouse | IgG2a | DCS-121 | Purified | Hu | IP, WB |
0.1 mg /
€400.00
|
| OriGene Technologies GmbH | |||||||























+8 additional images















