CHMP4B antibody
Principal name
CHMP4B antibody
Alternative names for CHMP4B antibody
C20orf178, SHAX1, CHMP4b, SNF7-2, hSnf7-2, Vps32-2, hVps32-2, Charged multivesicular body protein 4b, Chromatin-modifying protein 4b, SNF7 homolog associated with Alix 1, Vacuolar protein sorting-associated protein 32-2
Ncbi ID
NP_789782.1, NM_176812, NP_789782, NP_083638.1, NM_029362, BC011429
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of CHMP4B antibody
The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP4B (charged multivesicular body protein 4b) is a 224 amino acid protein that interacts with Alix, which results in the redistribution of Alix from the cytoplasm to the perinuclear area. Overexpression of CHMP4B induces accumulation of ubiquinated proteins and inhibits degradation of endocytosed EGF. Defects in the gene encoding CHMP4B can cause posterior polar cataract type 3 (CTPP3), a disease characterized by distinct opacity located at the back of the lens resulting in visual impairment and eventual blindness.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA349803 | CHMP4B antibody |
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| Rabbit Polyclonal Anti-CHMP4B Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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| AP31897PU-N | CHMP4B antibody |
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 |
Rabbit | Purified | Hu | C, E, WB |
0.1 mg /
€450.00
|
||
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP307637 | CHMP4B |
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| Recombinant protein of human chromatin modifying protein 4B (CHMP4B) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY406132 | CHMP4B overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR202622L2V | Lenti ORF particles, Chmp4b (GFP-tagged) - Mouse chromatin modifying protein 4B (cDNA clone MGC:19416 IMAGE:3485793), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€840.00
|
|
| OriGene Technologies, Inc. | ||
| MR202607L2V | Lenti ORF particles, Chmp4b (GFP-tagged) - Mouse chromatin modifying protein 4B (Chmp4b), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR202622L1V | Lenti ORF particles, Chmp4b (Myc-DDK-tagged) - Mouse chromatin modifying protein 4B (cDNA clone MGC:19416 IMAGE:3485793), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€740.00
|
|
| OriGene Technologies, Inc. | ||
| MR202607L1V | Lenti ORF particles, Chmp4b (Myc-DDK-tagged) - Mouse chromatin modifying protein 4B (Chmp4b), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||