CHMP4C antibody
Principal name
CHMP4C antibody
Alternative names for CHMP4C antibody
SHAX3, SNF7-3, hSnf7-3, hVps32-3, Charged multivesicular body protein 4c, Chromatin-modifying protein 4c, Vacuolar protein-sorting-associated protein 32-3,SNF7 homolog associated with Alix 3
Ncbi ID
9606, NP_689497.1, NM_152284, NP_689497, NP_079795.1, NM_025519, NM_001017466
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of CHMP4C antibody
Borealin interacts directly with Snf7/Shrb/CHMP4 components in both Drosophila and human cells and the two proteins colocalize at the midbody in late cytokinesis. Aurora B phosphorylates CHMP4C at three serine residues located in its C-terminal linker region, a part of the protein known to regulate its ability to form polymers and interact with the membrane. Over-expression of CHMP4C variants mutated in these three residues caused cytokinesis failure, suggesting that Aurora B inhibits CHMP4C activity during cytokinesis. It is proposed that CPC controls abscission timing in both flies and human cells by regulating the function of ESCRT-III Snf7 proteins during cytokinesis through the interaction of its Borealin component with the N-terminus of Shrb/CHMP4 proteins and Aurora B-mediated phosphorylation of the CHMP4C regulatory linker tail.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA890004 | CHMP4C antibody |
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| Rabbit polyclonal CHMP4C Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | P, WB |
0.1 ml /
€345.00
|
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP304802 | CHMP4C |
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| Recombinant protein of human chromatin modifying protein 4C (CHMP4C) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY407666 | CHMP4C overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR211120L2V | Lenti ORF particles, Chmp4c (GFP-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR211120L1V | Lenti ORF particles, Chmp4c (Myc-DDK-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||