CIS1 antibody
Principal name
CIS1 antibody
Alternative names for CIS1 antibody
CIS-1, CISH, G18, Cytokine-inducible SH2-containing protein, Suppressor of cytokine signaling
Ncbi ID
9606, NP_037456.5, NP_037456, NM_009895, NM_145071, NM_013324, NP_034025.1
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)
Background of CIS1 antibody
CISH(cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
General readings
1. Hu, G., Zhou, R., Liu, J., Gong, A.-Y., Eischeid, A. N., Dittman, J. W., Chen, X.-M. MicroRNA-98 and
let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in
response to microbial challenge. J. Immun. 183: 1617-1624, 2009.
2. Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D.,
Rautanen, A., Mills, T. C., Chang, K.-C., Kam, K.-M., Crampin, A. C., and 23 others. CISH and
susceptibility to infectious diseases. New Eng. J. Med. 362: 2092-2101, 2010.
3. Uchida, K., Yoshimura, A., Inazawa, J., Yanagisawa, K., Osada, H., Masuda, A., Saito, T., Takahashi,
T., Miyajima, A., Takahashi, T. Molecular cloning of CISH, chromosome assignment to 3p21.3, and
analysis of expression in fetal and adult tissues. Cytogenet. Cell Genet. 78: 209-212, 1997
Lysates
| Catalog No. | ||
|---|---|---|
| LY403423 | CISH overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY429375 | CISH overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC225377L2V | Lenti ORF particles, CISH (mGFP-tagged) - Human cytokine inducible SH2-containing protein (CISH), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,020.00
|
|
| OriGene Technologies, Inc. | ||