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Claudin-9 / CLDN9 antibody

Principal name

Claudin-9 / CLDN9 antibody

SwissProt ID

O95484 (Human), Q9Z0S7 (Mouse)

Gene ID

9080 (CLDN9)

Ncbi ID

NP_066192, NP_066192.1, NM_020982

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Rat

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of Claudin-9 / CLDN9 antibody

Claudin 9 belongs to the claudin family which constitutes a large group of four - transmembrane domain proteins (1). Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of paracellular transport and c ell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2). Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin family, including Claudi n 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3,4) .

General readings

Katoh,M. and Katoh,M., (2003) Int. J. Mol. Med. 11 (6), 683-689

Human HepG2; WB Suggested Anti-CLDN9 Antibody Titration: 2.0ug/ml. Positive Control: HepG2 cell lysate; CLDN9 antibody - C-terminal region (ARP33617_T100) in Human HepG2 cells using Western Blot

ARP33617_T100

SDS-PAGE analysis of purified YD-4E9 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 μg of purified YD-4E9 antibody. Proteins were separated by SDS-PAGE and stained with RAPID Stain TM Reagent

AM26751PU-N

AM26751PU-N. BOSC23 cells were transiently transfected with an expression vector encoding either Claudin 9 (red curve) or an irrelevant protein (control transfectant). Binding of YD-4E9 was detected with a PE conjugated secondary antibody. A positive signal was obtained only with Claudin 9 transfected cells.

AM26751PU-N

Western blot analysis of Claudin 9 expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates.

TP308701

WB Suggested Anti-CLDN9 Antibody Titration: 2.0 ug/ml; Positive Control: HepG2 cell lysate

TA334197

Primary Antibodies

Catalog No.	Host	Iso.	Clone	Pres.	React.	Applications
AM26751PU-N	Claudin-9 / CLDN9 antibody
	Rat	IgG2b	YD-4E9	Purified	Hu	E, F	0.1 mg / €380.00
							OriGene Technologies GmbH
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Proteins & Growth Factors

Catalog No.	Species	Purity	Source
TP308701	Claudin-9 / CLDN9
	Recombinant protein of human claudin 9 (CLDN9)
	Human	> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
				OriGene Technologies, Inc.

Lysates

Catalog No.
LY412160	CLDN9 overexpression lysate
		0.1 mg / €295.00
		OriGene Technologies, Inc.

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