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CYR61 antibody

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Principal name

CYR61 antibody

Alternative names for CYR61 antibody

CCN1, GIG1, IGFBP10, IBP10, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IGF-binding protein 10, CCN family member 1

SwissProt ID

O00622 (Human), P18406 (Mouse), Q9ES72 (Rat)

Gene ID

3491 (CYR61), 16007 (Cyr61), 83476

Ncbi ID

NP_001545.2, 9606, NP_001545, AAH01271.1, O00622, NM_001554, NM_010516, NM_031327

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Sh (Sheep), Chk (Chicken), Xen (Xenopus), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CYR61 antibody

Cysteine-rich angiogenic inducer 61(CYR61) or CCN family member 1(CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. This gene is mapped to 1p22.3. CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

AP00299PU-N - CYR61
Western blot analysis of Cyr 61 expression with lysate from Jurkat cells (Lane 1) and mouse small intestine tissue (Lane 2).
AP02087SU-S - CYR61
Figure 3. Sample of the transition zone in human hip osteonecrosiss: A 1/500 dilution of AP02087SU was incubated 4h at room temprature with fixed cells (with permission from J Orthop Res (Radke et al., 2006).
AP02087SU-S - CYR61
Figure 2. Human Primary Chondrocytes: A 1/500 dilution of AP02087SU was incubated 4h at room temprature with fixed Cells.
AP02087SU-S - CYR61
Figure 1. Human Primary Chondrocytes: Negative Control.
AP02088SU-S - CYR61
Figure 1. Samples from ovine fracture callus. A 1/500 dilution of antibody was used. Figure with permission by J Orthop Res (Lienau et al., 2006)
AM09007PU-N - CYR61
Immunohistochemistry: AM09007PU-N CYR61 antibody staining of Human Breast Cancer Tissue Paraffin Embedded Sections at 1/50 dilution for 2 hours at RT. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB).
AM09007PU-N - CYR61
Western blot analysis: The cell lysates of Jurkat (40 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CYR61 (1: 250). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
AP15515PU-S - CYR61
AP15515PU CYR61 antibody staining of Human Colon.
MAB2043 - CYR61
The cell lysate of Jurkat ( 40 µg ) was resolved by SDS-PAGE and probed with CYR61 monoclonal antibody, clone 3H3 ( Cat # MAB2043 ) ( 1: 250 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
PAB12525 - CYR61
Staining of CYR61 on human endometrium using CYR61 polyclonal antibody ( Cat # PAB12525 ). Photo courtesy of Dr. rer. nat. Isabella Gashaw, University Duisburg-Essen.
CEK1133 - Human CYR61 ELISA Kit
Representative Standard Curve
TA590733 - CYR61
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-CYR61 rabbit polyclonal antibody. (TA590733)
TA590733 - CYR61
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-CYR61 rabbit polyclonal antibody. (TA590733)
TA590733 - CYR61
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-CYR61 polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
TA590733 - CYR61
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CYR61 (RC203492, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CYR61.
TA590733 - CYR61
ELISA: CYR61 Antibody
TP723064 - CYR61
TA309618 - CYR61
Immunohistochemistry: CYR61 antibody - Human endometrium. Photo courtesy of Dr. rer. nat. Isabella Gashaw, Universität Duisburg-Essen
TA309618 - CYR61
Immunohistochemistry: CYR61 antibody - Human endometrium. Photo courtesy of Dr. rer. nat. Isabella Gashaw, Universität Duisburg-Essen
TA353776 - CYR61
Human Colon stained with anti-CYR61 antibody.
TA329157 - CYR61
Host: Rabbit; Target Name: CYR61; Sample Tissue: COLO205 Whole Cell lysates; Antibody Dilution: 3.0ug/ml

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CYR61 antibody
Figure 3. Sample of the transition zone in human hip osteonecrosiss: A 1/500 dilution of AP02087SU was incubated 4h at room temprature with fixed cells (with permission from J Orthop Res (Radke et al., 2006). Rabbit Serum Hu C, P, WB
0.1 ml / €500.00
  OriGene Technologies GmbH
+2 additional images

CYR61 antibody
Figure 3. Sample of the transition zone in human hip osteonecrosiss: A 1/500 dilution of AP02087SU was incubated 4h at room temprature with fixed cells (with permission from J Orthop Res (Radke et al., 2006). Rabbit Serum Hu C, P, WB
20 µl / €170.00
  OriGene Technologies GmbH
+2 additional images

CYR61 antibody
Immunohistochemistry using anti CYR61 antibody cat.no. AP02088SU-xx in paraffin sections of sheep fracture callus at different points of healing (1/400 dilution, ABC method).Figure A: The antibody stains the cytoplasm of active osteoblasts (arrows) but not of fibroblast-like osteoblasts (arrow heads).Figure C: CYR61 was also detected in pre-osteocytes in newly formed trabecular bone (arrows) and in some osteoclasts (arrow head).Figure with permission by J Orthop Res 24, Lienau J et al.(2006) Rabbit Serum Hu, Rt, Sh C, P, WB
0.1 ml / €500.00
  OriGene Technologies GmbH

CYR61 antibody
Immunohistochemistry using anti CYR61 antibody cat.no. AP02088SU-xx in paraffin sections of sheep fracture callus at different points of healing (1/400 dilution, ABC method).Figure A: The antibody stains the cytoplasm of active osteoblasts (arrows) but not of fibroblast-like osteoblasts (arrow heads).Figure C: CYR61 was also detected in pre-osteocytes in newly formed trabecular bone (arrows) and in some osteoclasts (arrow head).Figure with permission by J Orthop Res 24, Lienau J et al.(2006) Rabbit Serum Hu, Rt, Sh C, P, WB
20 µl / €170.00
  OriGene Technologies GmbH

4 Item(s)

per page

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Product Type
  1. Primary Antibody (4)
Clonality
  1. Polyclonal (4)
Target
  1. CYR61 (4)
Reactivity
  1. Human (Hu) (4)
  2. Rat (Rt) (2)
  3. Sheep (Sh) (2)
Presentation
  1. Serum (4)
Host
  1. Rabbit (4)
Images
  1. 1 image (4)
  2. 3+ images (2)
Images: Applications
  1. Paraffin Sections (P) (4)
  2. IHC (2)
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