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Decorin antibody

Principal name

Decorin antibody

Alternative names for Decorin antibody

DCN, SLRR1B, Bone proteoglycan II, PG-S2, PG40

SwissProt ID

O46542 (Horse), P07585 (Human), P21793 (Bovin), P28654 (Mouse), P28675 (Chick), Q01129 (Rat), Q28888 (Rabit), Q29393 (Canfa), Q5R1V9 (Pantr), Q9TTE2 (Sheep), Q9XSD9 (Pig)

Gene ID

1634 (DCN), 13179 (Dcn), 29139

Ncbi ID

NP_001911.1, 9606, NP_001177380.1, NP_001911, NP_598010, NP_598013, NM_001920, NM_001190451, NM_007833, NM_024129, NM_133504, NM_133506

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Can (Canine), Por (Porcine), African clawed frog

Available hosts

Sheep, Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of Decorin antibody

Decorin is a proteoglycan on average 90 - 140 kilodaltons (kD) in size. The human decorin gene spans more than 38 kb and contains 8 exons and very large introns, 2 of which are 5.4 and more than 13.2 kb. And the human decorin gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for the decorin gene. Mutations in the decorin gene are associated with congenital stromal corneal dystrophy.

General readings

Zafiropoulos A, Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN: Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. Molecular cancer research : MCR 2008 May 6 (5): 785-94. PMID: 18505923

Immunoperoxidase of monoclonal antibody to DCN on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 3 ug/ml]

H00001634-M01

Detection limit for recombinant GST tagged DCN is approximately 1ng/ml as a capture antibody.

H00001634-M01

Uterus, Endometrium: Formalin-Fixed Paraffin-Embedded (FFPE)

AP07546PU-N

Detection limit for recombinant GST tagged DCN is approximately 1ng/ml as a capture antibody.

H00001634-M02

Western Blot analysis of DCN expression in transfected 293T cell line (H00001634-T01) by DCN MaxPab polyclonal antibody.Lane 1: DCN transfected lysate(39.70 KDa).Lane 2: Non-transfected lysate.

H00001634-D01P

DCN MaxPab polyclonal antibody. Western Blot analysis of DCN expression in rat brain.

H00001634-B01P

Western Blot analysis of DCN expression in transfected 293T cell line (H00001634-T01) by DCN MaxPab polyclonal antibody.Lane 1: DCN transfected lysate(39.49 KDa).Lane 2: Non-transfected lysate.

H00001634-B01P

Western blot analysis of DCN in Jurkat cell lysate

PAB9509

Western blot analysis of DCN polyclonal antibody expression in Jurkat cell lysate.

PAB9510

Western blot analysis of DCN antibody (Center) (AP17272PU-N) in mouse heart tissue lysates (35 µg/lane). DCN (arrow) was detected using the purified Pab.

AP17272PU-N

Human Skin; Skin; DCN antibody - N-terminal region (ARP48199_P050) in Human Skin cells using Immunohistochemistry

ARP48199_P050

Human Placenta; WB Suggested Anti-DCN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Placenta; DCN antibody - N-terminal region (ARP48199_P050) in Human Placenta cells using Western Blot

ARP48199_P050

Human Heart; WB Suggested Anti-DCN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Human heart; DCN antibody - C-terminal region (ARP48200_P050) in Human Heart cells using Western Blot

ARP48200_P050

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

AM20879PU-N

Human Soft tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)

AM20879PU-N

Western Blot analysis of DCN expression in transfected 293T cell line. Lane 1: DCN transfected lysate (Predicted MW: 39.7 KDa). Lane 2: Non-transfected lysate.

AM20879PU-N

Detection limit for recombinant GST tagged DCN is approximately 1 ng/ml as a capture antibody.

AM20879PU-N

Representative Standard Curve

CEK1136

Representative Standard Curve

CEK1450

Immunohistochemistry: Decorin Antibody - Immunohistochemical staining for decorin (DCN) in Exocrine glandular and islet cells of normal human pancreas stained negative. Several pancreas cancers and occasional cases of other malignancies showed strong cytoplasmic staining. These images are the courtesy of the Human Proteome Resource (HPR).

TA590297

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-DCN Rabbit Polyclonal antibody. (TA590297)

TA590297

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-DCN Rabbit Polyclonal antibody. (TA590297)

TA590297

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-DCN Rabbit Polyclonal antibody. (TA590297)

TA590297

Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-DCN Rabbit Polyclonal antibody. (TA590297)

TA590297

Immunohistochemistry: Decorin Antibody - Immunohistochemical staining for decorin (DCN) in human pancreatic cancer. Several pancreas cancers and occasional cases of other malignancies showed strong cytoplasmic staining. These images are the courtesy of the Human Proteome Resource (HPR).

TA590297

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCN (RC212223, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCN.

TA590297

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-DCN Polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

TA590297

ELISA: Decorin Antibody

TA590297

TP302753

TP312223

TP318427

TA305696 (0.5ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TA305696

Western blot analysis of Decorin in Jurkat cell lysate.

TA318940

Western blot analysis of Decorin in Jurkat cell lysate.

TA318941

Western blot analysis of extracts of various cell lines, using DCN antibody.

TA327131

Immunofluorescence analysis of MCF7 cell using DCN antibody. Blue: DAPI for nuclear staining.

TA327131

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (DCN Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

TA349293

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using (DCN Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

TA349293

Primary Antibodies

Catalog No.	Host	Iso.	Clone	Pres.	React.	Applications
TA590297	Decorin antibody
	Rabbit Polyclonal Decorin Antibody
	Rabbit	IgG		Purified	Hu, Ms	E, P, WB	0.1 mg / €409.00
							OriGene Technologies, Inc.
+8 additional images	Highly validated antibody!
TA305696	Decorin antibody
	Goat Anti-Decorin Antibody
	Goat			Aff - Purified	Bov, Cavia, Hu, Por	WB	0.1 mg / €360.00
							OriGene Technologies, Inc.
TA318940	Decorin antibody
	Rabbit polyclonal anti-Decorin antibody
	Rabbit			Purified	Hu, Ms, Por, Rb, Rt	WB	0.1 mg / €380.00
							OriGene Technologies, Inc.
TA318941	Decorin antibody
	Rabbit polyclonal anti-Decorin antibody
	Rabbit			Aff - Purified	Hu, Ms, Por, Rb, Rt	WB	0.1 mg / €380.00
							OriGene Technologies, Inc.
TA327131	Decorin antibody
	DCN Rabbit Polyclonal Antibody
	Rabbit	IgG		Purified	Hu, Ms, Rt		0.1 mg / €335.00
							OriGene Technologies, Inc.
+1 additional image
TA349293	Decorin antibody
	Rabbit Polyclonal Anti-DCN Antibody
	Rabbit	IgG		Purified	Hu, Ms, Rt	E, P	0.1 ml / €335.00
							OriGene Technologies, Inc.
+1 additional image
AP07546PU-N	Decorin (6-19) antibody
	Sheep			Purified	Bov, Chk, Hu	E, P	50 µg / €425.00
							OriGene Technologies GmbH
AP17272PU-N	Decorin antibody
	Rabbit				Hu, Ms	WB	0.4 ml / €415.00
							OriGene Technologies GmbH
AP23409PU-N	Decorin (C-term) antibody
	Rabbit	IgG		Aff - Purified	Hu, Ms, Rt	WB	0.1 mg / €390.00
							OriGene Technologies GmbH
BP801	Decorin (316-329) antibody
	Sheep			Purified	Bov, Chk, Hu	E, WB	1 ml / €440.00
							OriGene Technologies GmbH
DM3538P	Decorin antibody
	Rat	IgG2	9A38	Purified	Ms	WB	0.1 mg / €460.00
							OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No.	Species	Pres.	Purity	Source
TP302753	Decorin (transcript variant A1)
	Recombinant protein of human decorin (DCN), transcript variant A1
	Human		> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
					OriGene Technologies, Inc.

TP312223	Decorin (transcript variant A2)
	Recombinant protein of human decorin (DCN), transcript variant A2
	Human		> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
					OriGene Technologies, Inc.

TP318427	Decorin (transcript variant D)
	Recombinant protein of human decorin (DCN), transcript variant D
	Human		> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
					OriGene Technologies, Inc.

AR51876PU-N	Decorin (31-359, His-tag)
	Human	Purified	> 80 % by SDS - PAGE	E. coli	0.25 mg / €820.00
					OriGene Technologies GmbH
AR51876PU-S	Decorin (31-359, His-tag)
	Human	Purified	> 80 % by SDS - PAGE	E. coli	50 µg / €320.00
					OriGene Technologies GmbH

ELISA Kits

Catalog No.
EA100474	Human Decorin ELISA Kit
		1 kit / €560.00
		OriGene Technologies, Inc.
EA100475	Mouse Decorin ELISA Kit
		1 kit / €500.00
		OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.
RR208005L2V	Lenti ORF particles, Dcn (GFP-tagged ORF) - Rat decorin (Dcn), 200 uL, >10^7 TU/mL
		200 µl / €930.00
		OriGene Technologies, Inc.

RR208005L1V	Lenti ORF particles, Dcn (Myc-DDK-tagged ORF) - Rat decorin (Dcn), 200 uL, >10^7 TU/mL
		200 µl / €830.00
		OriGene Technologies, Inc.

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