DEDD2 antibody
Principal name
DEDD2 antibody
Alternative names for DEDD2 antibody
FLAME3, FLAME-3, PSEC0004, FADD-like anti-apoptotic molecule 3, DEDD-2, DNA-binding death effector domain-containing protein 2, DED-containing protein FLAME-3
Ncbi ID
9606, NP_579874.1, NM_133328, AAH13372.2, NP_579874, NP_997560.3, NM_207677
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)
Background of DEDD2 antibody
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (1). A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis (3). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306113 | DEDD2 antibody |
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| Rabbit Polyclonal DEDD2 Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR204459L2V | Lenti ORF particles, Dedd2 (GFP-tagged) - Mouse death effector domain-containing DNA binding protein 2 (Dedd2), 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR204459L1V | Lenti ORF particles, Dedd2 (Myc-DDK-tagged) - Mouse death effector domain-containing DNA binding protein 2 (Dedd2), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||