Desert hedgehog / DHH antibody
Principal name
Desert hedgehog / DHH antibody
Alternative names for Desert hedgehog / DHH antibody
HHG-3
Ncbi ID
NP_031883, 9606, NP_066382.1, NP_031883.1, NP_066382, NM_007857, NM_021044
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)
Background of Desert hedgehog / DHH antibody
Desert Hedgehog (Dhh) belongs to the highly conserved Hedgehog family of proteins which are involved in multiple developmental processes. Hedgehogs are synthesized as 45 kDa precursors that are cleaved autocatalytically. The 19 kDa Nterminal fragment remains membrane associated due to its cholesterol and palmitate modifications. Binding of this fragment to Patched receptors results in the loss of Patched repression of Smoothened signaling. Dhh binds both Patched and Patched 2 as well as Hedgehog interacting protein (Hip). Within the N-terminal peptide, mouse Dhh shares 97% and 100% amino acid (aa) sequence identity with human and rat Dhh, respectively. It shares 74% aa seqeuence identity with mouse Indian (Ihh) and Sonic hedgehog (Shh). Dhh is produced by Sertoli cells and is required for testis development and spermatogenesis. It induces steroidogenic factor 1 which is instrumental in promoting Leydig cell differentiation. It also promotes the deposition of basal lamina surrounding seminiferous tubules. In humans, mutations of Dhh are associated with pure gonadal dysgenesis. Dhh is expressed in the female by ovarian granulosa cells and the corpus luteum. Its upregulation in human ovarian cancer correlates positively with proliferative index and negatively with prognosis. Dhh is also expressed by Schwann cells and is upregulated following nerve injury. It induces the expression of Patched and Hip in nerve fibroblasts and promotes the formation of the connective tissue sheath surrounding peripheral nerves.
General readings
Chen YJ, et al. (2007). Cell Cycle. 6(15):1826-30.Van den Brink GR., et al. (2007). Physiol Rev. 87(4):1343-75
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA308606 | Desert hedgehog / DHH antibody |
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| Rabbit polyclonal antibody to Dhh (desert hedgehog homolog (Drosophila)) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA351138 | Desert hedgehog / DHH antibody |
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| Rabbit Polyclonal Anti-DHH Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| DM3539P | Desert hedgehog / DHH (N-term) antibody |
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|
Rat | IgG2 | 6A12 | Purified | Ms | WB |
0.1 mg /
€460.00
|
| OriGene Technologies GmbH | |||||||
| DM3540P | Desert hedgehog / DHH (C-term) antibody |
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|
Rat | IgG2 | 7C8 | Purified | Ms | WB |
0.1 mg /
€460.00
|
| OriGene Technologies GmbH | |||||||
| GT15067-100 | Desert hedgehog / DHH antibody |
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|
Goat | Purified | Ms | C, E, ICC/IF, WB |
0.1 mg /
€450.00
|
||
| Neuromics Antibodies | |||||||
| MO15112-500 | Desert hedgehog / DHH antibody |
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|
Rat | IgG2a | 237208 | Purified | Ms | E, WB |
0.5 mg /
€410.00
|
| Neuromics Antibodies | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP760621 | Desert hedgehog / DHH (N-term HIS tag) |
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| Purified recombinant protein of Human desert hedgehog (DHH), with N-terminal HIS tag, expressed in E.Coli, 50ug | |||||
 |
Human | > 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
50 µg /
€205.00
|
|
| OriGene Technologies, Inc. | |||||
