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Desmoplakin antibody

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Principal name

Desmoplakin antibody

Alternative names for Desmoplakin antibody

DP, DSP, 250/210 kDa paraneoplastic pemphigus antigen

SwissProt ID

P15924 (Human)

Gene ID

1832 (DSP)

Ncbi ID

NP_001008844, NP_001008844.1

Available reactivities

Amph (Amphibian), Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Fi (Fish), Ze (Zebrafish)

Available hosts

Mouse, Guinea Pig, Rabbit, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Desmoplakin antibody

Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

AP31969PU-N - Desmoplakin
Desmoplakin antibody Cat.-No AP31969PU-N staining of paraffin embedded Human Heart at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
TA350652 - Desmoplakin
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using (DSP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
TA350652 - Desmoplakin
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (DSP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desmoplakin antibody
  Rabbit Polyclonal Anti-DSP Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using (DSP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

Desmoplakin antibody
  Rabbit Polyclonal Anti-DSP Antibody  
Desmoplakin Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Desmoplakin (1672 -1684) antibody
Desmoplakin antibody Cat.-No AP31969PU-N staining of paraffin embedded Human Heart at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €380.00
  OriGene Technologies GmbH

Desmoplakin antibody
Desmoplakin Rabbit Purified Hu C, E, WB
0.1 mg / €450.00
  OriGene Technologies GmbH

CRISPR

Catalog No. Species Donor Vector  

DSP - human gene knockout kit via CRISPR
DSP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DSP - human gene knockout kit via CRISPR
DSP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DSP - human gene knockout kit via CRISPR
DSP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DSP - human gene knockout kit via CRISPR
DSP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

8 Item(s)

per page

Available Filters

Product Type
  1. CRISPR (4)
  2. Primary Antibody (4)
Clonality
  1. Polyclonal (4)
Target
  1. Desmoplakin (4)
Property
  1. 1672 -1684 (1)
Reactivity
  1. Human (Hu) (4)
  2. Mouse (Ms) (3)
  3. Rat (Rt) (1)
Applications
  1. Enzyme Immunoassay (E) (4)
  2. Paraffin Sections (P) (3)
  3. Frozen sections (C) (1)
  4. Western blot / Immunoblot (WB) (1)
Presentation
  1. Purified (3)
  2. Aff - Purified (1)
Host
  1. Rabbit (3)
  2. Goat (1)
Images
  1. 1 image (2)
Images: Applications
  1. IHC (1)
  2. Paraffin Sections (P) (1)
Species (CRISPR)
  1. Human (4)
Donor Vector
  1. GFP-Puro (1)
  2. Luciferase-Puro (1)
  3. RFP-BSD (1)
  4. mBFP-Neo (1)
Manufacturer
  1. OriGene Technologies (8)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
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