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DLG1 antibody

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Principal name

DLG1 antibody

Alternative names for DLG1 antibody

Disks large homolog 1, Synapse-associated protein 97, SAP-97

SwissProt ID

Q12959 (Human), Q62696 (Rat), Q811D0 (Mouse)

Gene ID

1739 (DLG1), 25252 (Dlg1), 13383

Ncbi ID

9606, NP_036920.1, NM_004087, NP_001091894.1, NP_031888.2, NM_007862, NM_012788, NM_001098424

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of DLG1 antibody

Synapse-Associated Protein 97 (SAP97/human homologue of Drosophila discs-large tumor supressor or HDLG) is one of a family of plasma membrane-associated proteins found in synaptic junctions. This is a novel, presynaptic membrane protein homologous to SAP90 and the Drosophila discs-large tumor supressor protein. SAP97 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP97 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and Shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between SAP97 and other proteins. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP97 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP97 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

General readings

Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W.
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7. Epub 2006 Dec 15.
PMID: 17172448

H00001739-M01 - DLG1
Proximity Ligation Analysis (PLA) of protein-protein interactions between LCK and DLG1. HeLa cells were stained with anti-LCK rabbit purified polyclonal 1:1200 and anti-DLG1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.
PAB11517 - DLG1
DLG1 polyclonal antibody ( Cat # PAB11517 ) ( 0.3 µg/ml ) staining of Kelly lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence.
75-030 - DLG1
Adult rat hippocampus immunohistochemistry.
75-030 - DLG1
Immunoblot versus brain lysates from SAP97 wild-type (WT), knockout (KO) and heterozygous (Het) adult mice using K64/15 pure at 1 μg/mL (data courtesy of Lauren Makuch and Dr. Richard Huganir, Johns Hopkins University School of Medicine).
75-030 - DLG1
Adult rat brain membrane immunoblot
75-030 - DLG1
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebralcortex [HBM(Cx)], and hippocampus [HBM(H)].
73-030 - DLG1
Adult rat hippocampus immunohistochemistry.
73-030 - DLG1
Immunoblot versus brain lysates from SAP97 wild-type (WT), knockout (KO) and heterozygous (Het) adult mice using K64/15 pure at 1 μg/mL (data courtesy of Lauren Makuch and Dr. Richard Huganir, Johns Hopkins University School of Medicine).
73-030 - DLG1
Adult rat brain membrane immunoblot
73-030 - DLG1
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebralcortex [HBM(Cx)], and hippocampus [HBM(H)].
TA305843 - DLG1
TA305843 (0.3ug/ml) staining of KELLY lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA326524 - DLG1
Western blot analysis of SAP97 on rat brain membrane tissues using a 1:1000 dilution of the antibody
TA326524 - DLG1
IHC analysis of SAP97 in frozen sections of mouse brain extract using the antibody
  1. Quick-Filters:
  2. Highly Validated (2)

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLG1 antibody
Adult rat hippocampus immunohistochemistry. Mouse IgG1 K64/15 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €490.00
  Antibodies Incorporated
+3 additional images

Highly validated antibody!

NeuroMab

DLG1 antibody
Adult rat hippocampus immunohistochemistry. Mouse IgG1 K64/15 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €570.00
  Antibodies Incorporated
+3 additional images

Highly validated antibody!

NeuroMab

DLG1 antibody
  Goat Anti-DLG1 Antibody  
TA305843 (0.3ug/ml) staining of KELLY lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

DLG1 antibody
  Mouse Monoclonal Anti-SAP97 Antibody  
Western blot analysis of SAP97 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S64-15 Purified Hu, Ms, Rt WB
0.1 mg / €410.00
  OriGene Technologies, Inc.
+1 additional image

Lysates

Catalog No.    

DLG1 overexpression lysate
DLG1 overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DLG1 (mGFP-tagged) - Human discs, large homolog 1 (Drosophila) (DLG1), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, DLG1 (mGFP-tagged) - Human discs, large homolog 1 (Drosophila) (DLG1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,010.00
  OriGene Technologies, Inc.
 

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dlg1 (GFP-tagged) - Mouse discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Dlg1 (GFP-tagged) - Mouse discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL  
200 µl / €1,780.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Dlg1 (Myc-DDK-tagged) - Mouse discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Dlg1 (Myc-DDK-tagged) - Mouse discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL  
200 µl / €1,600.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dlg1 (GFP-tagged ORF) - Rat discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Dlg1 (GFP-tagged ORF) - Rat discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Dlg1 (Myc-DDK-tagged ORF) - Rat discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Dlg1 (Myc-DDK-tagged ORF) - Rat discs, large homolog 1 (Drosophila) (Dlg1), 200 uL, >10^7 TU/mL  
200 µl / €1,590.00
  OriGene Technologies, Inc.
 

10 Item(s)

per page

Available Filters

Product Type
  1. Human Lenti ORF Particle (1)
  2. Lysate (1)
  3. Mouse Lenti ORF Particle (2)
  4. Primary Antibody (4)
  5. Rat Lenti ORF Particle (2)
Clonality
  1. Monoclonal (3)
  2. Polyclonal (1)
Target
  1. DLG1 (4)
Reactivity
  1. Human (Hu) (4)
  2. Mouse (Ms) (4)
  3. Rat (Rt) (4)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Frozen sections (C) (2)
  3. Immunoprecipitation (IP) (2)
  4. Enzyme Immunoassay (E) (1)
Presentation
  1. Purified (2)
  2. Aff - Purified (1)
  3. Supernatant (1)
Host
  1. Mouse (3)
  2. Goat (1)
Images
  1. 1 image (4)
  2. 3+ images (2)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Frozen sections (C) (2)
  3. IHC (1)
Manufacturer
  1. OriGene Technologies (8)
  2. Antibodies Incorporated (2)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
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  • orders: ordering-de@origene.com
 
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