DPYD antibody
Principal name
DPYD antibody
Alternative names for DPYD antibody
DHPDHase, DPD, Dihydrouracil dehydrogenase, Dihydrothymine dehydrogenase, Dihydropyrimidine dehydrogenase [NADP+]
SwissProt ID
O89000 (Rat), Q12882 (Human), Q28007 (Bovin), Q28943 (Pig), Q8CHR6 (Mouse), Q96TH1 (Human)
Ncbi ID
9606, NP_000101.2, NM_000110, NP_000101, NP_740748.1, NM_170778, NM_031027, NM_001160301
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of DPYD antibody
DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.
General readings
Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Diasio, R. B. Initial characterization of the
molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer
Res. (Abstract) 36: 211 only, 1995.
2. McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R.
B., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzales, F.
J. Nomenclature for human DPYD alleles. Pharmacogenetics 8: 455-459, 1998.
3. Ridge, S. A., Brown, O., McMurrough, J., Fernandez-Salguero, P., Evans, W. E., Gonzalez, F. J.,
McLeod, H. L. Mutations at codon 974 of theDPYD gene are a rare event. Brit. J. Cancer 75:
178-179, 1997.
- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA327106 | DPYD antibody |
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| DPYD Rabbit Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
|
||
| OriGene Technologies, Inc. | |||||||
 +3 additional images |
Highly validated antibody! |
||||||
| TA308200 | DPYD antibody |
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| Rabbit polyclonal antibody to DPYD (dihydropyrimidine dehydrogenase) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | P, WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| +1 additional image |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP316374 | DPYD |
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| Recombinant protein of human dihydropyrimidine dehydrogenase (DPYD) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€788.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY424917 | DPYD overexpression lysate |
|
 |
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR211476L2V | Lenti ORF particles, Dpyd (GFP-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,920.00
|
|
| OriGene Technologies, Inc. | ||
| MR211476L1V | Lenti ORF particles, Dpyd (Myc-DDK-tagged) - Mouse dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,730.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR210325L2V | Lenti ORF particles, Dpyd (GFP-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,280.00
|
|
| OriGene Technologies, Inc. | ||
| RR210325L1V | Lenti ORF particles, Dpyd (Myc-DDK-tagged ORF) - Rat dihydropyrimidine dehydrogenase (Dpyd), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,060.00
|
|
| OriGene Technologies, Inc. | ||
