Dynactin subunit 2 antibody

Background of Dynactin subunit 2 antibody

DCTN2 is a 50-kD subunit of dyctin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dyctin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dyctin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dyctin subunits. It may interact directly with the largest subunit (p150) of dyctin and may affix p150 in place.This gene encodes a 50-kD subunit of dyctin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dyctin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dyctin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dyctin subunits. It may interact directly with the largest subunit (p150) of dyctin and may affix p150 in place. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.