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ENAC delta / SCNN1D antibody

Principal name

ENAC delta / SCNN1D antibody

Alternative names for ENAC delta / SCNN1D antibody

Delta-ENaC, ENaCD, SCNED, Delta-NaCH, DNACH, Amiloride-sensitive sodium channel subunit delta, Epithelial Na(+) channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta

SwissProt ID

P51172 (Human)

Gene ID

6339 (SCNN1D)

Ncbi ID

9606, NP_001123885, NP_001123885.2, NP_002969, NM_002978, NM_001130413

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ENAC delta / SCNN1D antibody

The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, α, β, γ and δ. The most frequently formed heterotetramer consists of 2α, 1β, and 1γ subunit, but the α subunit can be replaced by a δ subunit. The αENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the β and γENaC genes map to human chromosome 16p12, and the γENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle’s syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.

Western blot (WB) analysis of ENaCδ antibody (Cat.-No.: AP01381PU-N) in extracts from HEK293A cells.

AP01381PU-N

Western Blot analysis of SCNN1D expression in transfected 293T cell line (H00006339-T02) by SCNN1D MaxPab polyclonal antibody.Lane 1: SCNN1D transfected lysate(70.20 KDa).Lane 2: Non-transfected lysate.

H00006339-D01P

Immunofluorescence analysis of A549 cells, using SCNN1D Antibody. The picture on the right is treated with the synthesized peptide.

Western blot analysis of extracts from RAW264.7 cells, using SCNN1D Antibody. The lane on the right is treated with the synthesized peptide.

Western blot analysis of Delta-NaCH expression in HEK293A (A); MDA-MB231 (B) whole cell lysates.

Western blot analysis of extracts from RAW264.7 cells, using SCNN1D antibody.The lane on the right is treated with the synthesized peptide.

TA314516

Immunofluorescence analysis of A549 cells, using SCNN1D antibody.The picture on the right is treated with the synthesized peptide.

TA314516

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA314516	ENAC delta / SCNN1D antibody
	Rabbit polyclonal anti-SCNN1D antibody
	Rabbit	IgG	Purified	Hu	E, ICC/IF, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image
AP01381PU-N	ENAC delta / SCNN1D antibody
	Rabbit		Aff - Purified	Hu	E, WB	0.1 mg / €370.00
						OriGene Technologies GmbH

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