ERCC3 antibody
Principal name
ERCC3 antibody
Alternative names for ERCC3 antibody
ERCC-3, XPB, XPBC, BTF2-p89, TFIIH basal transcription factor complex helicase XPB subunit, Basic transcription factor 2 89 kDa subunit, TFIIH 89 kDa subunit, DNA repair protein complementing XP-B cells, Xeroderma pigmentosum group B-complementing protein, DNA excision repair protein ERCC-3
Ncbi ID
9606, NP_000113, NM_000122, NP_000113.1, NM_133658, NM_001031644
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)
Background of ERCC3 antibody
XPB and XPD are ATPase/helicase subunits of the TFIIH complex that are involved in nucleotide excision repair (NER) to remove lesions and photoproducts generated by UV light . XPB and XPD are 3’-5’ and 5’-3’ D helicases, respectively, that play a role in opening of the D damage site to facilitate repair . XPB and XPD both play an important role in maintaining genomic stability, and researchers have linked mutations of these proteins to Xeroderma Pigmentosum (XP) and Trichothiodystrophy (TTD). XP patients have abnormalities in skin pigmentation and are highly susceptible to skin cancers, while TTD patients exhibit symptoms such as brittle hair, neurological abnormalities, and mild photosensitivity . In addition to their role in NER, XPB and XPD are involved in transcription initiation as part of the TFIIH core complex . The helicase activity of XPB unwinds D around the transcription start site to facilitate R polymerase II promoter clearance and initiation of transcription . XPD plays a structural role linking core TFIIH components with the cdk-activating kise (CAK) complex that phosphorylates the C-terminus of the largest subunit of R polymerase II, leading to transcription initiation .
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA308754 | ERCC3 antibody |
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| Rabbit polyclonal antibody to XPB (excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms | ICC/IF, WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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| TA323737 | ERCC3 antibody |
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| Anti-ERCC3 Rabbit Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA327151 | ERCC3 antibody |
||||||
| ERCC3 Rabbit Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY424913 | ERCC3 overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR210632L2V | Lenti ORF particles, Ercc3 (GFP-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,580.00
|
|
| OriGene Technologies, Inc. | ||
| MR210632L1V | Lenti ORF particles, Ercc3 (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,420.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR215076L2V | Lenti ORF particles, Ercc3 (GFP-tagged ORF) - Rat excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,580.00
|
|
| OriGene Technologies, Inc. | ||
| RR215076L1V | Lenti ORF particles, Ercc3 (Myc-DDK-tagged ORF) - Rat excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,420.00
|
|
| OriGene Technologies, Inc. | ||