ERCC6L antibody
Principal name
ERCC6L antibody
Alternative names for ERCC6L antibody
PICH, Tumor antigen BJ-HCC-15, FLJ20105, DNA excision repair protein ERCC-6-like, ATP-dependent helicase ERCC6-like, PLK1-interacting checkpoint helicase
Ncbi ID
9606, NP_060139, NM_017669, NP_060139.2, NP_666347.2, NM_146235
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP), Paraffin Sections (P)
Background of ERCC6L antibody
PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA349940 | ERCC6L antibody |
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| Rabbit Polyclonal Anti-ERCC6L Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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Lysates
| Catalog No. | ||
|---|---|---|
| LY413630 | ERCC6L overexpression lysate |
|
 |
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR211843L2V | Lenti ORF particles, Ercc6l (GFP-tagged) - Mouse excision repair cross-complementing rodent repair deficiency complementation group 6 - like (Ercc6l), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,230.00
|
|
| OriGene Technologies, Inc. | ||
| MR211843L1V | Lenti ORF particles, Ercc6l (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency complementation group 6 - like (Ercc6l), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,010.00
|
|
| OriGene Technologies, Inc. | ||