ERN2 / IRE2 antibody
Principal name
ERN2 / IRE2 antibody
Alternative names for ERN2 / IRE2 antibody
Inositol-requiring protein 2, Ire1-beta, Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2
Gene ID
10595 (ERN2)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)
Background of ERN2 / IRE2 antibody
The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
General readings
Iwawaki, T. et al., Nat. Cell Biol. 3(2): 158-164 (2001)
Niwa, M. et al., Cell 99(7): 691-702 (1999)
Wang, X.Z. et al., EMBO J. 17(19): 5708-5717 (1998)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA351166 | ERN2 / IRE2 antibody |
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| Rabbit Polyclonal Anti-ERN2 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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| AP13752PU-N | ERN2 / IRE2 (N-term) antibody |
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 |
Rabbit | Ig | Purified | Hu, Ms | WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
| AP13753PU-N | ERN2 / IRE2 (C-term) antibody |
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 |
Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC224780L2V | Lenti ORF particles, ERN2 (mGFP-tagged) - Human endoplasmic reticulum to nucleus signaling 2 (ERN2), 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€2,130.00
|
|
| OriGene Technologies, Inc. | ||