FAIM3 / TOSO antibody
Principal name
FAIM3 / TOSO antibody
Alternative names for FAIM3 / TOSO antibody
Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso
Ncbi ID
9606, NP_001135945.1, NP_005440.1, NM_005449, NM_001193338, NP_005440, NP_081252.1, NM_026976, NM_001014843, NM_001142472
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)
Background of FAIM3 / TOSO antibody
Apoptosis is an important process in maintaining normal tissue homeostasis and function. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas associated death domain (FADD), containing death inducing signalling complex, and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7 (Curting and Cotter, 2003). Recent experiments have shown that overexpression of FAIM3, a novel regulator of Fas induced apoptosis in lymphoid cells, Jurkat cells and in transgenic mice renders these cells resistant to Fas induced apoptosis but not to TRAIL induced apoptosis (Hitoshi et al, 1998; Song and Jacob, 2005). Furthermore, FAIM3 was found to associate with FADD, suggesting that it functions by disrupting the formation of the death inducing signalling complex. Despite its predicted molecular weight, FAIM3 often migrates at 60 kDa in SDS PAGE.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306040 | FAIM3 / TOSO antibody |
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| Rabbit Polyclonal Toso Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | E, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA507395 | FAIM3 / TOSO antibody |
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| FAIM3 mouse monoclonal antibody, clone OTI1E6 (formerly 1E6) | |||||||
 |
Mouse | IgG1 | OTI1E6 | Purified | Hu | P |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
|
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| AP05598PU-N | FAIM3 / TOSO (C-term) antibody |
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 |
Rabbit | IgG | Purified | Hu | WB |
0.1 mg /
€410.00
|
|
| OriGene Technologies GmbH | |||||||
| AP07299PU-N | FAIM3 / TOSO antibody |
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 |
Rabbit | Purified | Hu | P, WB |
50 µg /
€425.00
|
||
| OriGene Technologies GmbH | |||||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY401671 | FAIM3 overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY434149 | FAIM3 overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR200550L2V | Lenti ORF particles, Faim3 (GFP-tagged ORF) - Rat Fas apoptotic inhibitory molecule 3 (Faim3), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||