Ficolin-2 antibody
Principal name
Ficolin-2 antibody
Alternative names for Ficolin-2 antibody
FCN2, FCNL, Ficolin2, Ficolin-B, Ficolin-beta, L-ficolin, Serum lectin p35, 37 kDa elastin-binding protein, EBP-37, Hucolin, Collagen/fibrinogen domain-containing protein 2
Ncbi ID
9606, NP_004099, NP_004099.2, NP_034320.1, NM_015837, NP_056652, NM_004108, NM_010190, NM_053634
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E)
Background of Ficolin-2 antibody
Ficolins are members of the collectin family of proteins which recognize PAMP on microbial surfaces. Human and murine ficolins differ in many aspects. Mouse has two ficolin forms, termed ficolin-A and -B. Mouse ficolin-A is the plasma protein, highly expressed in liver and spleen. Mouse ficolin-B is expressed in spleen, bone marrow, and peritoneal macrophages. It is thought to facilitate phagocytosis and is involved in the activation of complement pathways.
Structure: Ficolin consists of a short N-terminal, the middle collagen-like domain and C-terminal fibrionogen domain. The collagen-like domain assemble the subunits into trimers and the N-terminal domain further assembles four trimers into 12-mers.
Distribution: In contrast to human ficolin B, mouse ficolin B is mainly produced by macrophages.
Function: Recognize pathogen-associated molecular pattern ( PAMP) on microbial surface to facilitate phagocytosis. In addition, it can activate complement through a calcium-dependent association with MASPs.
Lysates
| Catalog No. | ||
|---|---|---|
| LY414367 | FCN2 overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
