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FNTB antibody

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Principal name

FNTB antibody

Alternative names for FNTB antibody

FTase-beta, CAAX farnesyltransferase subunit beta, Protein farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta

SwissProt ID

P49355 (Bovin), P49356 (Human), Q02293 (Rat), Q8K2I1 (Mouse)

Gene ID

100529261 (CHURC1-FNTB), 64511 (Fntb), 2342 (FNTB), 110606

Ncbi ID

NP_002019, 9606, NP_002019.1, NP_742031.1, NP_666039.1, NM_172034, NM_002028

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of FNTB antibody

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

General readings

Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Fontaine-Bisson, B., et al. J. Mol. Med. (2009) In press.
Zhou, J., et al. J. Biol. Chem. 284(15):9648-9655(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

PAB4316 - FNTB
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FNTB polyclonal antibody ( Cat # PAB4316 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
H00002342-M01 - FNTB
Detection limit for recombinant GST tagged FNTB is approximately 3ng/ml as a capture antibody.
AP01497PU-N - FNTB
Western blot (WB) analysis of FTβ antibody (Cat.-No.: AP01497PU-N) in extracts from RAW264.7 cells.
AP12189PU-N - FNTB
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AP12189PU-N - FNTB
Western blot analysis of FNTB (arrow) using FNTB Antibody (N-term) (Cat.#AP12189PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FNTB gene (Lane 2) (Origene Technologies).
C17991-1 - FNTB
Western blot analysis of extracts from RAW264.7/NIH-3T3 cells, using FNTB Antibody. The lane on the right is treated with the synthesized peptide.
AP51695PU-N - FNTB
Western blot analysis of FNTB Antibody (N-term) (Cat.-No AP51695PU-N in CEM cell line lysates (35ug/lane). This demonstrates the FNTB antibody detected the FNTB protein (arrow).
CPA3223-100ul - FNTB
Western blot analysis of FNTB expression in K562 (A); A431 (B); Raw264.7 (C); PC12 (D) whole cell lysates.
TP305858 - FNTB
TA311940 - FNTB
Western blot analysis of extracts from 3T3 cells and RAW264.7 cells, using FNTB antibody.The lane on the right is treated with the synthesized peptide.
TA344328 - FNTB
WB Suggested Anti-Fntb Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Thymus

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FNTB antibody
  Rabbit polyclonal anti-FNTB antibody  
Western blot analysis of extracts from 3T3 cells and RAW264.7 cells, using FNTB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

FNTB antibody
Western blot (WB) analysis of FTβ antibody (Cat.-No.: AP01497PU-N) in extracts from RAW264.7 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  OriGene Technologies GmbH

FNTB (N-term) antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+1 additional image

FNTB (N-term) antibody
Western blot analysis of FNTB Antibody (N-term) (Cat.-No AP51695PU-N in CEM cell line lysates (35ug/lane). This demonstrates the FNTB antibody detected the FNTB protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

4 Item(s)

per page

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Product Type
  1. Primary Antibody (4)
Target
  1. FNTB (4)
Property
  1. N-term (2)
Reactivity
  1. Human (Hu) (4)
  2. Mouse (Ms) (2)
  3. Rat (Rt) (2)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Enzyme Immunoassay (E) (1)
  3. Paraffin Sections (P) (1)
Presentation
  1. Aff - Purified (2)
  2. Purified (2)
Host
  1. Rabbit (4)
Images
  1. 1 image (4)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Paraffin Sections (P) (1)
Manufacturer
  1. OriGene Technologies (4)
Service
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