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Fucosyltransferase 4 antibody

Principal name

Fucosyltransferase 4 antibody

Alternative names for Fucosyltransferase 4 antibody

Fucosyltransferase IV, FUT4, ELFT, FCT3A, Fuc-TIV, Alpha-(1,3)-fucosyltransferase, Galactoside 3-L-fucosyltransferase, ELAM-1 ligand fucosyltransferase

SwissProt ID

P22083 (Human), Q11127 (Mouse), Q62994 (Rat), Q8HZR3 (Bovin)

Gene ID

2526 (FUT4), 14345 (Fut4)

Ncbi ID

NP_002024.1, NP_002024, NM_010242, NM_002033

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of Fucosyltransferase 4 antibody

Fucosyltransferases (FucTs) catalyze the covalent association of fucose to different positional linkages on sugar acceptor molecules. The carbohydrate moieties that are generated are covalently attached to cell surfaces and are necessary to ensure a surface contour that satisfies a variety of physiological roles. FucT-IV (alpha 1,3-fucosyltransferase IV), also known as FUT4, FCT3A or ELFT, is a 405 amino acid single-pass type II membrane protein that localizes to Golgi stacks. During embryogenesis, FucT-IV is highly expressed in skin, liver, kidney, muscle and small intestine where it functions to catalyze the glycosidic attachment of alpha-fucose to various molecules, such as N-acetyllactosamines. Via its catalytic activity, FucT-IV participates in the synthesis of carbohydrate molecules like the cell-adhesion antigen CD15 (also known as Lewis X), thereby playing a roll in cell cycle events such as apoptosis and cellcell binding. Overexpression of FucT-IV is implicated in epithelial cancers, suggesting a possible role for FucT-IV in carcinogenesis.

General readings

Yang, X.S., et al. J. Cell. Physiol. 225(2):612-619(2010)
Trubiani, O., et al. J. Cell. Physiol. 225(1):123-131(2010)
Pruszak, J., et al. Stem Cells 27(12):2928-2940(2009)
Ogata, K., et al. Haematologica 94(8):1066-1074(2009)
Read, T.A., et al. Cancer Cell 15(2):135-147(2009)

Immunohistochemistry (IHC) analyzes of FucT-IV antibody Cat.-No. AP20571PU-N in paraffin-embedded human breast carcinoma tissue.

AP20571PU-N

Immunohistochemistry (IHC) analyzes of FucT-IV antibody Cat.-No. AP20571PU-N in paraffin-embedded human breast carcinoma tissue at 1/100.

AP20571PU-N

Western blot (WB) analysis of FucT-IV antibody Cat.-No. AP20571PU-N at 1/500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: H9C2 whole cell lysate.

AP20571PU-N

Immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue reacted with FUT4 Antibody (C-term) Cat.-No AP51738PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining.

AP51738PU-N

Western blot analysis of FUT4 Antibody (C-term) Cat.-No AP51738PU-N in NCI-H460 cell line lysates (35ug/lane). This demonstrates the FUT4 antibody detected the FUT4 protein (arrow).

AP51738PU-N

Flow cytometric analysis of NCI-H460 cells using FUT4 Antibody (C-term) Cat.-No AP51738PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

AP51738PU-N

Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD15 Antibody-FITC labled.

CPA8338-100Assays - Fucosyltransferase 4

Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD15 Antibody-FITC labled.

Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD15 Antibody-PE labled.

Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD15 Antibody; followed by anti-mouse IgG PE.

Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD15 Antibody; followed by anti-mouse IgG PE.

Flow Cytometry: SSEA1 Antibody (MC-480) - FACS staining of NTERA-2 cells using anti-SSEA1 at a 1:50 dilution detected using Dylight-488 conjugated goat anti-mouse IgM secondary antibody.

TA309665

Human HK Lymphoma stained with anti-CD15 antibody.

TA353657

Flow cytometric analysis of rabbit anti-CD15 (SP159) antibody in HL-60 (green) compare to negative control of rabbit IgG (blue).

TA353657

Human HK Lymphoma stained with anti-CD15 antibody.

TA353657

Human Fallopian Tube stained with anti-CD15 antibody.

TA353657

Human Lung Adenocarcinoma stained with anti-CD15 antibody.

TA353657

Human Renal Cell Carcinoma stained with anti-CD15 antibody.

TA353657

Human Kidney stained with anti-CD15 antibody.

TA353657

Human Spleen stained with anti-CD15 antibody.

TA353657

Human Endometrium stained with anti-CD15 antibody.

TA353657

Human Stomach Adenocarcinoma stained with anti-CD15 antibody.

TA353657

Human Tonsil stained with anti-CD15 antibody.

TA353657

Human Esophagus stained with anti-CD15 antibody.

TA353657

Primary Antibodies

Catalog No.	Host	Iso.	Clone	Pres.	React.	Applications
TA309665	Fucosyltransferase 4 antibody
	Mouse Monoclonal SSEA1 Antibody (MC-480)
	Mouse	IgM	MC-480	Purified	Hu, Ms	C, F, ICC/IF, WB	0.1 ml / €415.00
							OriGene Technologies, Inc.
TA320337	Fucosyltransferase 4 antibody
	Mouse Anti-Human CD15 Purified (100 ug)
	Mouse		HI98	Purified	Hu	F, P	0.1 mg / €185.00
							OriGene Technologies, Inc.
AP20571PU-N	Fucosyltransferase 4 antibody
	Rabbit			Aff - Purified	Hu, Ms, Rt	P, WB	0.1 mg / €370.00
							OriGene Technologies GmbH
+2 additional images
AP51738PU-N	Fucosyltransferase 4 (C-term) antibody
	Rabbit	Ig		Purified	Hu	F, P, WB	0.4 ml / €415.00
							OriGene Technologies GmbH
+2 additional images

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