GALE antibody
Principal name
GALE antibody
Alternative names for GALE antibody
Galactowaldenase, UDP-glucose 4-epimerase, UDP-galactose 4-epimerase
Ncbi ID
9606, NP_001008217, NP_000394, NP_000394.2, NM_001008216, NM_000403, NM_001127621, NP_001121093, NP_848476.1
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)
Background of GALE antibody
GALE is an UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (\'peripheral\' form) to severe (\'generalized\' form). This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (\'peripheral\' form) to severe (\'generalized\' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
General readings
Holden HM., et al. (2003) J Biol Chem. 278(45):43885-8.
Timson DJ., et al. (2005) FEBS J. 272(23):6170-7.
- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA502146 | GALE antibody |
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| GALE mouse monoclonal antibody, clone OTI1C4 (formerly 1C4) | |||||||
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Mouse | IgG1 | OTI1C4 | Purified | Can, Hu, Mky, Rt | P, WB |
0.1 ml /
€379.00
|
| OriGene Technologies, Inc. | |||||||
 +11 additional images |
Highly validated antibody!
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| AP17410PU-N | GALE (Center) antibody |
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Rabbit | Hu | WB |
0.4 ml /
€415.00
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| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP301561 | GALE (transcript variant 1) |
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| Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 1 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP308709 | GALE (transcript variant 2) |
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| Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 2 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP325521 | GALE (transcript variant 3) |
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| Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 3 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP720236 | GALE (transcript variant 1) |
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| Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 1 | |||||
 |
Human | > 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
10 µg /
€299.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY423394 | GALE overexpression lysate |
|
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0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY424739 | GALE overexpression lysate |
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0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY426826 | GALE overexpression lysate |
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0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |