GPR120 antibody
Principal name
GPR120 antibody
Alternative names for GPR120 antibody
G-protein coupled receptor 120, PGR4, GPR129, GT01
Ncbi ID
NP_001182684.1, 9606, NP_861413.1, NM_181748, NM_181745, NM_001195755, NM_001047088
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunofluorescence (IF)
Background of GPR120 antibody
GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of Glucagon-like peptide-1 (GLP-1) in vivo and in vitro.GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake.GLP-1 also inhibits Glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.
General readings
- 1. GPR expression in the rat taste bud relating to fatty acid sensing.
Matsumura S, Mizushige T, Yoneda T, Iwanaga T, Tsuzuki S, Inoue K, Fushiki T.Biomed Res. 2007 Feb;28(1):49-55.
- 2. The regulation of adipogenesis through GPR120.
Gotoh C, Hong YH, Iga T, Hishikawa D, Suzuki Y, Song SH, Choi KC, Adachi T, Hirasawa A, Tsujimoto G, Sasaki S, Roh SG.Biochem Biophys Res Commun. 2007 Mar 9;354(2):591-7. Epub 2007 Jan 16.
- 3. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.
Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, Hirasawa A, Tsujimoto G.J Biol Chem. 2005 May 20;280(20):19507-15. Epub 2005 Mar 17.
- 4. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G.Nat Med. 2005 Jan;11(1):90-4. Epub 2004 Dec 26.
Western blot (WB) analysis of GPR120 antibody (Cat.-No.: AP01302PU-N) in extracts from LOVO cells.
Immunofluorescence analysis of HEK 293T cells overexpressing human GPR120, using GPR120 monoclonal antibody, clone 2B6 ( Cat # MAB1725 ) .
Formalin-Fixed, Paraffin-Embedded Human Small Intestine
Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. O3FAR1 / GPR120 antibody diluted at 1:2000.
Western blot analysis of GPR120 expression in HepG2 (A); HEK293T (B) whole cell lysates.
Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. TA308714 diluted at 1:2000.
Immunohistochemical analysis of paraffin-embedded Human prostate adenocarcinoma, using GPR120 (TA308714) antibody at 1:500 dilution.
Immunohistochemical analysis of paraffin-embedded Human prostate adenocarcinoma, using GPR120 (TA308714) antibody at 1:500 dilution.
Anti-O3FAR1 / GPR120 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human colon, crypts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human small intestine, enterocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-O3FAR1 / GPR120 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot analysis of GPR120 expression in PC12 cells
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA308714 | GPR120 antibody |
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| Rabbit polyclonal antibody to GPR120 (G protein-coupled receptor 120) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | P, WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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| TA317593 | GPR120 antibody |
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| GPR120 Rabbit Polyclonal (N-Terminus) Antibody | |||||||
 |
Rabbit | IgG | Purified | Gorilla, Hu, Mky |
50 µg /
€425.00
|
||
| OriGene Technologies, Inc. | |||||||
| TA317595 | GPR120 (C-term) antibody |
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| GPR120 Rabbit Polyclonal (C-Terminus) Antibody | |||||||
 |
Rabbit | Aff - Purified | Hu, Mky, Prim | P |
50 µg /
€425.00
|
||
| OriGene Technologies, Inc. | |||||||
| TA317632 | GPR120 antibody |
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| GPR120 Rabbit Polyclonal (Cytoplasmic Domain) Antibody | |||||||
 |
Rabbit | IgG | Purified | Bt, Hu, Mky, Rb |
50 µg /
€425.00
|
||
| OriGene Technologies, Inc. | |||||||
| +2 additional images |
|||||||
| TA347920 | GPR120 antibody |
||||||
| Rabbit Polyclonal Anti-GPR120 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP01302PU-N | GPR120 antibody |
||||||
 |
Rabbit | Aff - Purified | Hu, Ms, Rt | E, ICC/IF, WB |
0.1 mg /
€370.00
|
||
| OriGene Technologies GmbH | |||||||
| AP55674PU-N | GPR120 (1-71) antibody |
||||||
 |
Rabbit | IgG | Aff - Purified | Hu | P, WB |
50 µl /
€425.00
|
|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
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Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR205527L2V | Lenti ORF particles, Ffar4 (GFP-tagged) - Mouse omega-3 fatty acid receptor 1 (O3far1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR205527L1V | Lenti ORF particles, Ffar4 (Myc-DDK-tagged) - Mouse omega-3 fatty acid receptor 1 (O3far1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR202773L2V | Lenti ORF particles, Ffar4 (GFP-tagged ORF) - Rat G protein-coupled receptor 120 (Gpr120), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR202773L1V | Lenti ORF particles, Ffar4 (Myc-DDK-tagged ORF) - Rat G protein-coupled receptor 120 (Gpr120), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
