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HAP1 antibody

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Principal name

HAP1 antibody

Alternative names for HAP1 antibody

Huntingtin-associated protein 1, HAP-1, HAP2, HLP1, Neuroan 1

SwissProt ID

O35668 (Mouse), P54256 (Rat), P54257 (Human)

Gene ID

9001 (HAP1), 29430 (Hap1), 15114

Ncbi ID

NP_001073339.1, 10116, 9606, NP_077047, NP_034534.1., NM_177977, NM_001079871, CAC09418, NP_034534.1, NM_177981, NM_001079870

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of HAP1 antibody

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood.
Huntingtin-associated protein-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (Dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.

General readings

Takeshita Y, Fujinaga R, Zhao C, Yanai A, Shinoda K.
Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.
Hum Mol Genet. 2006 Aug 1;15(15):2298-312. Epub 2006 Jun 16.
PMID: 16782802

AP07303PU-N - HAP1
Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE)
AP07921PU-N - HAP1
Figure 1. AP07921PU-N HAP1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Adrenal tissue.
PAB0702 - HAP1
IHC on rat DRG ( free floating cryo section ) using rabbit Hap1 polyclonal antibody ( Cat # PAB0702 ) at a dilution of 1 : 1000.
PAB0702 - HAP1
IHC on rat spinal cord ( free floating cryo section ) using rabbit Hap1 polyclonal antibody ( Cat # PAB0702 ) at a dilution of 1 : 1000. Motor neurons are intensely stained.
PAB7160 - HAP1
HAP1 polyclonal antibody ( Cat # PAB7160 ) ( 0.1 µg/ml ) staining of human brain ( hippocampus ) lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence.
MAB2312 - HAP1
Western blot analysis of Hap1 in mouse brain lysate using Hap1 monoclonal antibody, clone 1B6 ( Cat # MAB2312 ).
MAB2312 - HAP1
Staining of rat hypothalamus using Hap1 monoclonal antibody, clone 1B6 ( Cat # MAB2312 ).
H00009001-D01P - HAP1
Western Blot analysis of HAP1 expression in transfected 293T cell line (H00009001-T01) by HAP1 MaxPab polyclonal antibody.Lane 1: HAP1 transfected lysate(73.81 KDa).Lane 2: Non-transfected lysate.
PAB12994 - HAP1
Immunohistochemistry of HAP1 in human brain tissue with HAP1 polyclonal antibody ( Cat # PAB12994 ) at 2.5 µg/ml.
PAB12994 - HAP1
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 polyclonal antibody ( Cat # PAB12994 ) at ( A ) 0.5 and ( B ) 1 µg/ml.
AP23773PU-N - HAP1
AP23773PU-N HAP-1 antibody staining of Mouse Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA303170 - HAP1
TA303170 (0.1µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA306425 - HAP1
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/ml.
TA306425 - HAP1
Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/ml.
TA306425 - HAP1
Immunofluorescence of HAP1 in Human Brain cells with HAP1 antibody at 20 ug/mL.
TA309681 - HAP1
Western Blot: HAP1 Antibody - Western blot analysis of HAP1 using Lane 1: mouse brain lysate and Lane 2: human brain lysate.
TA309681 - HAP1
Detection of HAP1 in mouse brain lysate using anti-HAP1.
TA309681 - HAP1
Staining of rat hypothalamus using anti-HAP1.

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

HAP1 (C-term) antibody
AP23773PU-N HAP-1 antibody staining of Mouse Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, WB
0.1 mg / €380.00
  OriGene Technologies GmbH
 

OriGene recommends this product for Western blotting.

HAP1 antibody
  Goat Polyclonal Antibody against HAP1  
TA303170 (0.1µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

HAP1 antibody
  Rabbit Polyclonal HAP1 Antibody  
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €415.00
  OriGene Technologies, Inc.
+2 additional images

HAP1 antibody
  Mouse Monoclonal HAP1 Antibody (1B6)  
Western Blot: HAP1 Antibody - Western blot analysis of HAP1 using Lane 1: mouse brain lysate and Lane 2: human brain lysate. Mouse IgG1 1B6 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €395.00
  OriGene Technologies, Inc.
+2 additional images

HAP1 antibody
Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €425.00
  OriGene Technologies GmbH

HAP1 (639-653) antibody
Figure 1. AP07921PU-N HAP1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Adrenal tissue. Rabbit Purified Hu E, P
50 µg / €425.00
  OriGene Technologies GmbH

Lysates

Catalog No.    

HAP1 overexpression lysate
HAP1 overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

HAP1 overexpression lysate
HAP1 overexpression lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

8 Item(s)

per page

Available Filters

Product Type
  1. Lysate (2)
  2. Primary Antibody (6)
Clonality
  1. Polyclonal (5)
  2. Monoclonal (1)
Target
  1. HAP1 (6)
Property
  1. 639-653 (1)
  2. C-term (1)
Reactivity
  1. Human (Hu) (5)
  2. Mouse (Ms) (4)
  3. Rat (Rt) (4)
Applications
  1. Western blot / Immunoblot (WB) (5)
  2. Enzyme Immunoassay (E) (4)
  3. Paraffin Sections (P) (3)
  4. Frozen sections (C) (1)
  5. Immunoprecipitation (IP) (1)
Presentation
  1. Aff - Purified (4)
  2. Purified (2)
Host
  1. Rabbit (3)
  2. Goat (2)
  3. Mouse (1)
Images
  1. 1 image (6)
  2. 3+ images (2)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. IHC (2)
  3. Paraffin Sections (P) (2)
  4. Immunofluorescence (IF) (1)
Manufacturer
  1. OriGene Technologies (8)
Service
  • OriGene Technologies GmbH
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  • Germany
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  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
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