Human IgG4 antibody
Principal name
Human IgG4 antibody
Alternative names for Human IgG4 antibody
Human Immunoglobulin G4
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)
Background of Human IgG4 antibody
IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma. Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/ IgG ratios (typically > 30%).
Secondary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AM00923PU-N | Human IgG4 (Fc specific) |
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 |
Mouse | IgG1 | BDI541 | Purified | Hu | C, E, WB |
5 mg /
€1,890.00
|
| OriGene Technologies GmbH | |||||||
| AM01158PU-N | Human IgG4 (pFC) |
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|
Mouse | IgG3 | HP6023 (also known as HO6023) | Purified | Hu | C, E, WB |
0.5 mg /
€560.00
|
| OriGene Technologies GmbH | |||||||
| AM10097SU-M | Human IgG4 |
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 |
Mouse | IgG1 | MRQ-44 | Supernatant | Hu | P |
1 ml /
€450.00
|
| OriGene Technologies GmbH | |||||||