Switch to Europe/Worldwide website Switch to German website Switch to French website Switch to OriGene Technologies, Inc. (North America)
Home » Target » Human IgM antibody

Human IgM antibody

(reset)

Principal name

Human IgM antibody

Alternative names for Human IgM antibody

Human Immunoglobulin M

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit, Goat, Donkey, Rat, Sheep

Available applications

Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Agglutination (AGG), Immunoprecipitation (IP), Immunodiffusion (ID), Dot blot (Dot), Functional assay (FN), Lateral Flow (LF), Radioimmunoassay (R)

Background of Human IgM antibody

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.

General readings

Franklin E.C.: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975;194:77-95.
Fuller JM, Keyser J.W.: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21(6):667-71.
Balogh Z, Meretey K, Falus A, Bozsoky S.: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129-34.
Brinkmann V, Heusser CH.: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152(2):323-32.

SM3063APC - Human IgM
Surface staining of Human peripheral blood cells with anti-Human IgM Antibody (CH2) APC conjuagetd Cat.-No SM3063APC. Cells in the lymphocyte gate were used for analysis.
SM3063P - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC. Cells in the lymphocyte gate were used for analysis.
GTX17150 - Human IgM
IHC Image using GTX17150 - Detection of IgM by IHC in Human Tonsil
GTX20772 - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (GTX20772): APC. Cells in the lymphocyte gate were used for analysis.
GTX20939 - Human IgM
Formalin fixed paraffin embedded human tonsil stained with IgM antibody (GTX17150).
GTX78349 - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC (GTX78350). Cells in the lymphocyte gate were used for analysis.
GTX78350 - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC (GTX78350). Cells in the lymphocyte gate were used for analysis.
NB120-17150 - Human IgM
Formalin fixed paraffin embedded human tonsil stained with IgM antibody.
NB120-939 - Human IgM
Immunohistochemistry-Paraffin: IgM Antibody [NB120-939]
NB500-468 - Human IgM
Fig. 1. Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC. Cells in the lymphocyte gate were used for analysis.
AM08147PU-N - Human IgM
B Cell Stimulation: 5 x 10e5 Human PBMC were incubated with the indicated concentrations of purified Mouse F(ab')2 Anti-Human IgM, clone UHB (#AM08147PU-N), for 48 hours. B cell proliferation was determined by 3H-Thymidine incorporation assay. Amount Used: < / = 10 µg/mL
MAB4495 - Human IgM
Surface staining of human peripheral blood cells with IgM monoclonal antibody, clone CH2 (APC) ( Cat # MAB4495 ).Cells in the lymphocyte gate were used for analysis.
MAB5555 - Human IgM
Immunoblot analysis of human plasma protein.Lane 1 : IgG isolated from human plasma.Lane 2 : Human plasma.
SM3063HRP - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC.Cells in the lymphocyte gate were used for analysis.
SM3063PE - Human IgM
Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC.Cells in the lymphocyte gate were used for analysis.
AP10433PU-N - Human IgM
Formalin-Fixed, Paraffin-Embedded Human lymph node stained with IgM antibody Cat.-No. AP10433PU-N using peroxidase conjugate and DAB chromogen. Note cytoplasmic staining of plasma cells.

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3

Secondary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 APC Hu ICC/IF
0.1 mg / €400.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 Biotin Hu E, ICC/IF
0.5 mg / €290.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 FITC Hu ICC/IF
0.5 mg / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 HRP Hu E
1 ml / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 Purified Hu C, Dot, E, ICC/IF, WB
0.5 mg / €230.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG1 SA-DA4 PE Hu ICC/IF
0.1 mg / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB AP Hu E
1 ml / €330.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB Biotin Hu E, ICC/IF
0.5 mg / €290.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB FITC Hu ICC/IF
0.5 mg / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB HRP Hu E
1 ml / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB Low Endotoxin Hu C, Dot, E, ICC/IF, WB
0.1 mg / €440.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB Purified Hu C, Dot, E, ICC/IF, WB
0.5 mg / €230.00
  OriGene Technologies GmbH

Human IgM (Mu chain specific)
Human IgM Mouse IgG3 UHB PE Hu F
0.1 mg / €310.00
  OriGene Technologies GmbH

Human IgM (Mu chain, Fab-Region)
B Cell Stimulation: 5 x 10e5 Human PBMC were incubated with the indicated concentrations of purified Mouse F(ab')2 Anti-Human IgM, clone UHB (#AM08147PU-N), for 48 hours. B cell proliferation was determined by 3H-Thymidine incorporation assay. Amount Used: < / = 10 µg/mL Mouse IgG3 UHB Purified Hu E, FN, ICC/IF
0.25 mg / €280.00
  OriGene Technologies GmbH

Human IgM
Human IgM Mouse IgG1 ICL-931 FITC Hu C, E
1 ml / €580.00
  OriGene Technologies GmbH

Human IgM
Human IgM Mouse IgG1 ICL-931 HRP Hu C, Dot, E, R
1 ml / €670.00
  OriGene Technologies GmbH

Human IgM
Human IgM Mouse IgG1 ICL-931 Purified Hu C, Dot, E, R
1 ml / €410.00
  OriGene Technologies GmbH

Human IgM
Human IgM Mouse IgG 47.2.E9 Purified Hu E
0.2 mg / €460.00
  OriGene Technologies GmbH

Human IgM
Human IgM Rat IgM HM-7 Aff - Purified Hu E
0.5 mg / €560.00
  OriGene Technologies GmbH

Human IgM
Human IgM Mouse IgG1 DM3A3 Purified Hu C, P
0.2 mg / €330.00
  OriGene Technologies GmbH

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3
52 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. Secondary Antibody (52)
Clonality
  1. Monoclonal (29)
  2. Polyclonal (23)
Target
  1. Human IgM (52)
Reactivity
  1. Human (Hu) (33)
Applications
  1. Enzyme Immunoassay (E) (22)
  2. Frozen sections (C) (14)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (10)
  4. Western blot / Immunoblot (WB) (7)
  5. Dot blot (Dot) (5)
  6. Paraffin Sections (P) (5)
  7. Flow cytometry (F) (3)
  8. Agglutination (AGG) (2)
  9. Radioimmunoassay (R) (2)
  10. Functional assay (FN) (1)
Presentation
  1. Purified (14)
  2. FITC (7)
  3. HRP (6)
  4. Biotin (5)
  5. AP (4)
  6. Aff - Purified (4)
  7. TRITC (3)
  8. Texas Red (3)
  9. PE (2)
  10. Supernatant (2)
  11. APC (1)
  12. Low Endotoxin (1)
Host
  1. Mouse (28)
  2. Goat (14)
  3. Rabbit (9)
  4. Rat (1)
Images
  1. 1 image (1)
Images: Applications
  1. Functional assay (FN) (1)
Manufacturer
  1. OriGene Technologies (47)
  2. HyTest Ltd. (5)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
© Copyright 1998 - 2018 OriGene Technologies GmbH
  • LinkedIn