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IL18BP antibody

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Principal name

IL18BP antibody

Alternative names for IL18BP antibody

Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa

SwissProt ID

O95998 (Human), Q9Z0M9 (Mouse)

Gene ID

16068 (Il18bp), 10068 (IL18BP)

Ncbi ID

NP_034661, 9606, NP_001034748, NP_001138529, NP_001034748.1, NP_766630, NP_034661.1, NM_001039659, NM_001039660, NM_001145055, NM_001145057

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of IL18BP antibody

IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells.
This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

General readings

Shimizu,C., et al. (2012) Mod Rheumatol 22 (1), 73-79Fujita,T.,et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69

H00010068-M05 - IL18BP
IL18BP monoclonal antibody (M05), clone 2A9 Western Blot analysis of IL18BP expression in MCF-7 ( Cat # L046V1 ).
H00010068-M05 - IL18BP
IL18BP monoclonal antibody (M05), clone 2A9 Western Blot analysis of IL18BP expression in K-562 ( Cat # L009V1 ).
H00010068-M05 - IL18BP
Detection limit for recombinant GST tagged IL18BP is approximately 3ng/ml as a capture antibody.
AR50764PU-N - IL18BP
CEK1217 - Human IL-18BP ELISA Kit
Representative Standard Curve
TA313228 - IL18BP
Western blot analysis of extracts from HepG2 and HeLa cells, using IL18BP antibody.The lane on the right is treated with the synthesized peptide.
TA323374 - IL18BP
Gel: 10%SDS-PAGE, Lysate: 60 µg, Lane: Human lymphoma tissue, Primary antibody: IL18BP Antibody at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
TA323375 - IL18BP
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using IL18BP antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)
TA336593 - IL18BP
Western Blot: IL18BP Antibody [TA336593] - WB detection of IL18BP in the lysate of spleen tissue with TA336593 at a dilution of 1:500
TA346979 - IL18BP
Western blot detection of IL18 binding protein in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18 binding protein mouse mAb (1:400-1:1000 diluted).Predicted band size:37KDa.Observed band size:37/40KDa.

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

IL18BP antibody
  Rabbit polyclonal anti-IL18BP antibody  
Western blot analysis of extracts from HepG2 and HeLa cells, using IL18BP antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

IL18BP antibody
  Anti-IL18BP Rabbit Polyclonal Antibody  
Gel: 10%SDS-PAGE, Lysate: 60 µg, Lane: Human lymphoma tissue, Primary antibody: IL18BP Antibody at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

IL18BP antibody
  Anti-IL18BP Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using IL18BP antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

IL18BP antibody
  Rabbit Polyclonal IL-18 BPa/IL18BP Antibody  
Western Blot: IL18BP Antibody [TA336593] - WB detection of IL18BP in the lysate of spleen tissue with TA336593 at a dilution of 1:500 Rabbit Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

IL18BP antibody
  Mouse Monoclonal IL18 binding protein Antibody  
Western blot detection of IL18 binding protein in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18 binding protein mouse mAb (1:400-1:1000 diluted).Predicted band size:37KDa.Observed band size:37/40KDa. Mouse IgG2b 5C7-D2-G4-B6 Purified WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

IL18BP antibody
IL18BP Goat Biotin Ms E, WB
25 µg / €250.00
  OriGene Technologies GmbH

IL18BP antibody
IL18BP Goat Biotin Ms E, WB
50 µg / €340.00
  OriGene Technologies GmbH

IL18BP antibody
IL18BP Goat Aff - Purified Ms E, WB
50 µg / €250.00
  OriGene Technologies GmbH

IL18BP antibody
IL18BP Goat Aff - Purified Ms E, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

IL18BP (transcript variant A)
  Purified recombinant protein of Human interleukin 18 binding protein (IL18BP), transcript variant A  
IL18BP Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
50 µg / €299.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, IL18BP (Myc-DDK tagged) - Human interleukin 18 binding protein (IL18BP), transcript variant F , 200 uL, >10^7 TU/mL
Lenti ORF particles, IL18BP (Myc-DDK tagged) - Human interleukin 18 binding protein (IL18BP), transcript variant F , 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

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Product Type
  1. Human Lenti ORF Particle (1)
  2. Primary Antibody (9)
  3. Protein | Growth Factor (1)
Clonality
  1. Polyclonal (8)
  2. Monoclonal (1)
Target
  1. IL18BP (10)
Reactivity
  1. Mouse (Ms) (6)
  2. Human (Hu) (4)
  3. Rat (Rt) (2)
Applications
  1. Western blot / Immunoblot (WB) (8)
  2. Enzyme Immunoassay (E) (7)
  3. Paraffin Sections (P) (2)
  4. Frozen sections (C) (1)
  5. Flow cytometry (F) (1)
  6. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
  7. Immunoprecipitation (IP) (1)
Presentation
  1. Purified (5)
  2. Aff - Purified (2)
  3. Biotin (2)
Host
  1. Goat (4)
  2. Rabbit (4)
  3. Mouse (1)
Images
  1. 1 image (5)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. IHC (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (11)
Service
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