INSIG2 antibody
Principal name
INSIG2 antibody
Alternative names for INSIG2 antibody
INSIG-2, Insulin-induced gene 2 protein
Ncbi ID
9606, NP_057217, NP_057217.2, NP_598509.1, NM_178082, NM_133748, NM_178091, NM_016133
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of INSIG2 antibody
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated sigling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.
General readings
Li,C.G., (2008) Int. J. Cancer 123 (2), 273-282
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA350094 | INSIG2 antibody |
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| Rabbit Polyclonal Anti-INSIG2 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP305274 | INSIG2 |
||||
| Recombinant protein of human insulin induced gene 2 (INSIG2) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR202632L2V | Lenti ORF particles, Insig2 (GFP-tagged) - Mouse insulin induced gene 2 (Insig2), transcript variant 1, 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR202627L2V | Lenti ORF particles, Insig2 (GFP-tagged) - Mouse insulin induced gene 2 (Insig2), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR202632L1V | Lenti ORF particles, Insig2 (Myc-DDK-tagged) - Mouse insulin induced gene 2 (Insig2), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
| MR202627L1V | Lenti ORF particles, Insig2 (Myc-DDK-tagged) - Mouse insulin induced gene 2 (Insig2), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR211993L2V | Lenti ORF particles, Insig2 (GFP-tagged ORF) - Rat insulin induced gene 2 (Insig2), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR211993L1V | Lenti ORF particles, Insig2 (Myc-DDK-tagged ORF) - Rat insulin induced gene 2 (Insig2), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||