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KCNB2 antibody

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Principal name

KCNB2 antibody

Alternative names for KCNB2 antibody

Voltage-gated potassium channel subunit Kv2.2, Potassium voltage-gated channel subfamily B member 2

SwissProt ID

A6H8H5 (Mouse), Q4ZHA6 (Bovin), Q63099 (Rat), Q92953 (Human), Q95167 (Canfa), Q95L11 (Rabit)

Gene ID

9312 (KCNB2), 117105 (Kcnb2), 98741

Ncbi ID

NP_004761, NP_004761.2, 10116, NP_446452.2, NP_001091998.1, NM_001098528, NM_004770

Available reactivities

Ms (Mouse), Rt (Rat), Xen (Xenopus), Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of KCNB2 antibody

KV2.2 is a member of the voltage-gated K+ channel superfamily. Together with the closely related KV2.1 protein they form the KV2 subfamily also known as Shab. As with all KV channels, KV2.2 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functiol KV channel is a tetramer that can either be a homotetramer or a heteromer of KV2.2 and KV2.1 subunits.Both KV2.2 and KV2.1 channels are known as delayed rectifiers that is, channels that are activated by changes in membrane potential (depolarization) but ictivate very slowly. The current they form is known as IK or IDR. Accessory subunits such as KChaP and the electrically silent a subunits KV8 and KV9 can modulate biochemical and biophysical properties of KV2.2. KV2.2 is expressed in the brain and in peripheral tissues such as gastrointestil and vascular smooth muscle. Physiologically, KV2.2 has a role in maintaining membrane potential and in modulating electrical excitability in neurons. In smooth muscle cells, KV2.2 is probably involved in maintaining the contractile capacity of the cells.The pharmacology of the KV2.2 channel is somewhat limited. The channel is blocked by the classical K+ channel blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP). More recently, the small peptide toxin Stromatoxin-1 has been found to be a potent and more specific inhibitor of the KV2 subfamily.

AP05196PU-N - KCNB2
Western blot analysis using Kv2.2 antibody on rat brain lysate in the absence and presence of antigen peptide.
75-015 - KCNB2
immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University).
75-015 - KCNB2
adult rat basal forebrain immunofluorescence with antigen retrieval via sodium citrate pretreatment with K37/89 (red) and Kv2.1 rabbit (green). Image courtesy of Kaori Misonou and Hiroaki Misonou (University of Maryland, now at Doshisha University, Japan).
75-015 - KCNB2
immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K37/89 TC supe
75-015 - KCNB2
immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with Myc-tagged Kv2.2short, GFP-tagged Kv2.2long or untagged Kv2.1 plasmid probed with K37/89 (left), K89/34 (middle) or N52A/42 (right) TC supe.
73-015 - KCNB2
immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University).
73-015 - KCNB2
adult rat basal forebrain immunofluorescence with antigen retrieval via sodium citrate pretreatment with K37/89 (red) and Kv2.1 rabbit (green). Image courtesy of Kaori Misonou and Hiroaki Misonou (University of Maryland, now at Doshisha University, Japan).
73-015 - KCNB2
immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K37/89 TC supe
73-015 - KCNB2
immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with Myc-tagged Kv2.2short, GFP-tagged Kv2.2long or untagged Kv2.1 plasmid probed with K37/89 (left), K89/34 (middle) or N52A/42 (right) TC supe.
73-358 - KCNB2
Adult rat brain immunohistochemistry
73-358 - KCNB2
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2 short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372C/51 (left) or N52A/42 (right) TC supe.
73-358 - KCNB2
Immunofluorescence staining of wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372C/51 (red) and Hoechst stain (blue)
73-369 - KCNB2
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe.
73-369 - KCNB2
Adult rat whole brain immunohistochemistry
73-369 - KCNB2
Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/1 (red) and Hoechst nuclear stain (blue).
73-360 - KCNB2
Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/60 (red) and Hoechst nuclear stain (blue).
73-360 - KCNB2
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid probed with N372B/60 (left), N372C/51 (middle) or N52A/42 (right) TC supe.
75-369 - KCNB2
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe.
75-369 - KCNB2
Adult rat whole brain immunohistochemistry
75-369 - KCNB2
Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/1 (red) and Hoechst nuclear stain (blue).
TA309217 - KCNB2
Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block).
TA326556 - KCNB2
IHC analysis of Kv2.2 in frozen sections of mouse brain extract using the antibody
TA328973 - KCNB2
Western blot analysis of rat brain lysate: 1. Anti-Kv2.2 antibody , (1:2000). 2. Anti-Kv2.2 antibody, preincubated with the control peptide antigen.
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNB2 antibody
  Rabbit Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody  
Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block). Rabbit IgG Aff - Purified Rt, Xen C, WB
0.1 ml / €405.00
  OriGene Technologies, Inc.
 

Published recently!

KCNB2 antibody
immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €490.00
  Antibodies Incorporated
+3 additional images

Highly validated antibody!

NeuroMab

KCNB2 antibody
immunoblot against adult rat brain membranes (RBM) and membranes from Kv2.2 wild-type (WT) and knockout (KO) mice probed with K37/89 (left) or K89/34 TC supe. Mouse brains courtesy of Amy Huntley and Jeanne Nerbonne (Washington University). Mouse IgG2a K37/89 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €570.00
  Antibodies Incorporated
+3 additional images

Highly validated antibody!

NeuroMab

KCNB2 antibody
  Mouse Monoclonal Anti-Kv2.2 Antibody  
IHC analysis of Kv2.2 in frozen sections of mouse brain extract using the antibody Mouse IgG2a S37-89 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €410.00
  OriGene Technologies, Inc.

KCNB2 antibody
  Rabbit polyclonal Anti-KV2.2  
Western blot analysis of rat brain lysate: 1. Anti-Kv2.2 antibody , (1:2000). 2. Anti-Kv2.2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.

KCNB2 antibody
Adult rat brain immunohistochemistry Mouse IgG1 N372C/51 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €490.00
  Antibodies Incorporated
+2 additional images

NeuroMab

KCNB2 antibody
Immunofluorescence staining of adult wild-type (WT) and Kv2.2 knockout (KO) mouse magnocellular preoptic nucleus (MCPO) with N372B/60 (red) and Hoechst nuclear stain (blue). Mouse IgG2b N372B/60 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €490.00
  Antibodies Incorporated
+1 additional image

NeuroMab

KCNB2 antibody
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €490.00
  Antibodies Incorporated
+2 additional images

NeuroMab

KCNB2 antibody
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372B/1 (left) or N52A/42 (right) TC supe. Mouse IgG1 N372B/1 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €570.00
  Antibodies Incorporated
+2 additional images

NeuroMab

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNB2 (mGFP-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL
Lenti ORF particles, KCNB2 (mGFP-tagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), 200 uL, >10^7 TU/mL  
200 µl / €2,020.00
  OriGene Technologies, Inc.
 

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnb2 (GFP-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Kcnb2 (GFP-tagged) - Mouse potassium voltage gated channel, Shab-related subfamily, member 2 (Kcnb2), 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.
 

11 Item(s)

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  1. Human Lenti ORF Particle (1)
  2. Mouse Lenti ORF Particle (1)
  3. Primary Antibody (9)
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Target
  1. KCNB2 (9)
Reactivity
  1. Rat (Rt) (9)
  2. Mouse (Ms) (8)
  3. Human (Hu) (6)
  4. Xenopus (Xen) (1)
Applications
  1. Western blot / Immunoblot (WB) (9)
  2. Frozen sections (C) (8)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (7)
  4. Immunoprecipitation (IP) (2)
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  2. Supernatant (4)
  3. Aff - Purified (1)
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  2. Rabbit (2)
Images
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Images: Applications
  1. Western blot / Immunoblot (WB) (8)
  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (6)
  3. Frozen sections (C) (3)
  4. IHC (1)
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Service
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