KCNH4 antibody
Principal name
KCNH4 antibody
Alternative names for KCNH4 antibody
KCNH4, ELK channel 1, ELK1, Brain-specific eag-like channel 2, BEC2, Voltage-gated potassium channel subunit Kv12.3, Ether-a-go-go-like potassium channel 1, Potassium voltage-gated channel subfamily H member 4
Ncbi ID
NP_036417, AAI40293.1, NM_012285, NP_446082.1, NP_036417.1, NM_053630
Available reactivities
Available hosts
Available applications
Flow Cytometry (F), Western blot / Immunoblot (WB)
Background of KCNH4 antibody
Kv12.3 (also known as elk3 and KCNH4) is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. These are the eag (Kv10) with two members, the eag-related channels (erg or Kv11) and the eag-like K+ channels (elk or Kv12) with three members each.As all members of the family, Kv12.3 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functiol channel is a tetramer composed of four subunits. It has been suggested that the Kv12 subfamily members can form functiol heteromultimers within the subfamily.Kv12.3 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as testis and lung. The physiological function of the Kv12.3 channel hasnâ??t been established, although a role in the modulation of overall excitability of neurons has been suggested. At the moment there isnâ??t much pharmacological data concerning the modulation of the Kv12.3 channel except for blocking of the channel by Ba2+.
General readings
Bailey, S.D., et al. Diabetes Care (2010) In press
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Zou, A., et al. Am. J. Physiol., Cell Physiol. 285 (6), C1356-C1366 (2003)
Miyake, A., et al. J. Biol. Chem. 274(35):25018-25025(1999)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA328971 | KCNH4 antibody |
||||||
| Rabbit polyclonal Anti-KV12.3 (Elk3) | |||||||
 |
Rabbit | Purified | Hu, Rt | WB |
0.2 ml /
€585.00
|
||
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
|||||||
| AP52304PU-N | KCNH4 (N-term) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu | F, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY415853 | KCNH4 overexpression lysate |
|
 |
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC212999L2V | Lenti ORF particles, KCNH4 (mGFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 4 (KCNH4), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,190.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR200598L2V | Lenti ORF particles, Kcnh4 (GFP-tagged ORF) - Rat potassium voltage-gated channel, subfamily H (eag-related), member 4 (Kcnh4), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,270.00
|
|
| OriGene Technologies, Inc. | ||
| RR200598L1V | Lenti ORF particles, Kcnh4 (Myc-DDK-tagged ORF) - Rat potassium voltage-gated channel, subfamily H (eag-related), member 4 (Kcnh4), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,040.00
|
|
| OriGene Technologies, Inc. | ||