KCNK4 antibody
Principal name
KCNK4 antibody
Alternative names for KCNK4 antibody
KCNK4, TRAAK, Potassium channel subfamily K member 4, Two pore K(+) channel KT4.1, TWIK-related arachidonic acid-stimulated potassium channel protein
Ncbi ID
NP_201567, NP_201567.1, AAI60128.1, NP_032457.1, NM_008431, NM_033310
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E)
Background of KCNK4 antibody
K2P4.1 (also med TWIK-related arachidonic acid stimulated K+ channel, TRAAK or KCNK4) is a member of the 2-pore (2P) domain K+ channels family that at the moment includes 15 members. These channels show little time or voltage dependence and are considered to be â??leakyâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a sigture topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. K2P4.1 can be integrated to a K2P subfamily that includes K2P2.1 (TREK1) and K2P10.1 (TREK2) that are activated by intracellular unsaturated fatty acids such as arachidonic acid, lysophosphatidic acid, high intracellular pH and mechanical stretch. K2P4.1 expression is largely confined to the brain in mouse samples while in humans it is also expressed in placenta and to a lesser degree in kidney, small intestine and prostate.
General readings
Mehrle,A., Nucleic Acids Res. 34 (DATABASE ISSUE), D415-D418 (2006)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA328664 | KCNK4 antibody |
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| Rabbit Polyclonal Anti-K2P4.1 (TRAAK) | |||||||
 |
Rabbit | Purified | Hu, Rt | WB |
0.2 ml /
€585.00
|
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| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP313846 | KCNK4 |
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| Recombinant protein of human potassium channel, subfamily K, member 4 (KCNK4) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
