Klotho antibody
Principal name
Klotho antibody
Alternative names for Klotho antibody
KL, Klotho, EC 3.2.1.31
Ncbi ID
9606, NP_038851.2, NP_004786, NM_033549, NP_004786.2, NM_004795, NM_013823, NM_031336
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Immunohistochemistry (IHC), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of Klotho antibody
Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon,. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating protein arises from the action of an as yet unidentified protease which cleaves transmembrane Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone derived hormone that acts in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally abolished.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA311313 | Klotho antibody |
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| Goat Anti-Klotho (KL) Antibody | |||||||
 |
Goat | Purified | Hu, Ms, Rt | P, WB |
0.1 mg /
€360.00
|
||
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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| TA319778 | Klotho antibody |
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| Rabbit Polyclonal KLOTHO Antibody | |||||||
 |
Rabbit | Aff - Purified | Hu, Ms, Rt | E, ICC/IF, P, WB |
0.1 mg /
€415.00
|
||
| OriGene Technologies, Inc. | |||||||
| +2 additional images |
|||||||
| TA350910 | Klotho antibody |
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| Rabbit Polyclonal Anti-KL Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP32851BT-N | Klotho antibody |
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 |
Rabbit | Biotin | Hu | E, WB |
50 µg /
€340.00
|
||
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
| AP32851BT-S | Klotho antibody |
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|
Rabbit | Biotin | Hu | E, WB |
25 µg /
€250.00
|
||
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
| AP32851PU-N | Klotho antibody |
||||||
 |
Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€340.00
|
||
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
| AP32851PU-S | Klotho antibody |
||||||
|
Rabbit | Aff - Purified | Hu | E, WB |
50 µg /
€250.00
|
||
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
| DM3583P | Klotho antibody |
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 |
Rat | IgG2 | 4F54 | Purified | Ms | C, WB |
0.1 mg /
€460.00
|
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP723263 | Klotho |
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| Purified recombinant protein of Human klotho (KL). | |||||
|
Human | > 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
CHO cells |
20 µg /
€230.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY417748 | KL overexpression lysate |
|
|
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR227101L1V | Lenti ORF particles, Kl (Myc-DDK-tagged) - Mouse klotho (Kl), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,720.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR213144L2V | Lenti ORF particles, Kl (GFP-tagged ORF) - Rat Klotho (Kl), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,260.00
|
|
| OriGene Technologies, Inc. | ||
| RR213144L1V | Lenti ORF particles, Kl (Myc-DDK-tagged ORF) - Rat Klotho (Kl), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,040.00
|
|
| OriGene Technologies, Inc. | ||