MBNL1 antibody
Principal name
MBNL1 antibody
Alternative names for MBNL1 antibody
Muscleblind-like protein 1, EXP
Gene ID
4154 (MBNL1)
Ncbi ID
9606, NP_997179, AAH50535, NP_997175, NP_066368, NM_021038, NM_207292, NM_207293, NM_207294, NM_207295, NM_207296, NP_997178, NP_997176, NP_997180, NP_066368.2
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)
Background of MBNL1 antibody
pre-mRs splicing /removal of non-coding regions is a critical process which contributes to a diverse proteome as well as gene expression regulation, and there are several splicing factors that are exclusively involved in a subset of splicing decisions - human muscleblind-like family of R-binding proteins: MBNL1/2/3 also known as MBNL/EXP, MBLL/MPL1, and MBXL/CHCR, respectively. Muscleblind-like 1 (MBNL1) is a known mediator of pre-mR altertive splicing regulation and it acts either as activator or repressor of splicing on specific pre-mR targets. Several pathologies are linked to expansion of polynucleotide sequences (mostly trinucleotide repeats) and CUG/CCUG expansion Rs accumulates in Myotonic Dystrophy patient cells wherein it contributes to the disease by dysregulating altertive splicing factors such as CUGBP, Elav-like Family Member 1 (CELF1) and MBNL1. The expanded CUG repeats sequester MBNL proteins into nuclear foci, leading to loss of active protein and the sequestration of MBNL1 leads to missplicing of developmentally regulated events that are responsible for symptoms in DM types 1 and 2, such as the missplicing of the chloride channel (CLCN1) leading to myotonia. CELF1 and MBNL1 regulate a number of common splicing events, but in opposite directions and loss of MBNL1 activity is more critical than upregulation of CELF1 activity for abnormal splicing.
General readings
Warf MB, Berglund JA.
MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T.
RNA. 2007 Dec;13(12):2238-51.
PMID: 17942744
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- Cited (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA305699 | MBNL1 (C-term) antibody |
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| Goat Anti-MBNL1 Antibody | |||||||
 |
Goat | Aff - Purified | Bov, Can, Hu, Ms, Rt | WB |
0.1 mg /
€360.00
|
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| OriGene Technologies, Inc. | |||||||
| TA336512 | MBNL1 antibody |
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| Mouse Monoclonal Muscleblind-like 1 Antibody (HL-1822 3A4-1E9) | |||||||
![Western Blot: Muscleblind-like 1 Antibody (HL-1822 3A4-1E9) [TA336512] - Detection of Muscleblind in HeLa whole cell extract (33ug) using NB 110-37256.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB110-37256-1-W.jpg) |
Mouse | IgG1 | HL-1822 3A4-1E9 | Purified | Hu, Ms, Rt | C, ICC/IF, P, WB |
0.5 ml /
€415.00
|
| OriGene Technologies, Inc. | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP323216 | MBNL1 (transcript variant 6) |
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| Recombinant protein of human muscleblind-like (Drosophila) (MBNL1), transcript variant 6 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
 +2 additional images |
Published recently! |
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| TP308112 | MBNL1 (transcript variant 1) |
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| Recombinant protein of human muscleblind-like (Drosophila) (MBNL1), transcript variant 1 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP319704 | MBNL1 (transcript variant 5) |
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| Recombinant protein of human muscleblind-like (Drosophila) (MBNL1), transcript variant 5 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP323104 | MBNL1 (transcript variant 3) |
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| Purified recombinant protein of Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 3 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP323199 | MBNL1 (transcript variant 7) |
||||
| Purified recombinant protein of Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 7 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY402822 | MBNL1 overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY404075 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY404076 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY404077 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY404078 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY404079 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY430988 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. | ||
| LY430989 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. | ||
| LY430990 | MBNL1 overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |