MDM4 antibody
Principal name
MDM4 antibody
Alternative names for MDM4 antibody
MDMX, MDM-4, Double minute 4 protein, Mdm2-like p53-binding protein, p53-binding protein Mdm4
SwissProt ID
O15151 (Human), O35618 (Mouse), Q2HJ21 (Bovin), Q5XIN1 (Rat), Q7ZUW7 (Danre), Q7ZYI3 (Xenla)
Ncbi ID
9606, NP_002384, NP_002384.2, NM_008575, NM_001012026, NM_002393
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of MDM4 antibody
MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
General readings
Gilkes,D.M., (2008) Mol. Cell. Biol. 28 (6), 1999-2010











Western blot analysis of phosphorylated MdmX (Ser367) expression in MCF7. MCF cells were preincubated with the proteasome inhibitor MG132 (20 µM) and exposed to DNA damaging agent, adriamycin (3 µM) or etoposide (20 µM), for the indicated periods. The cell lysates were used for immunoprecipitation with anti-MdmX antibody (D-19). The immunocomplex was resolved on SDS-PAGE and immunoblotted with anti-MdmX antibody, AM26541AF-S and anti-14-3-3 ß antibody.



















































- Quick-Filters:
- Cited (1)
- Highly Validated (6)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA505706 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4B5 (formerly 4B5) | |||||||
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Mouse | IgG1 | OTI4B5 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€379.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Published recently! Highly validated antibody! |
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| TA505722 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI1D11 (formerly 1D11) | |||||||
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Mouse | IgG2a | OTI1D11 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA505723 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4G5 (formerly 4G5) | |||||||
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Mouse | IgG2b | OTI4G5 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| TA505735 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI3H2 (formerly 3H2) | |||||||
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Mouse | IgG2b | OTI3H2 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| TA505736 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) | |||||||
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Mouse | IgG2a | OTI2D11 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| AM06258SU-N | MDM4 antibody |
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Mouse | IgG1 | 2D10F4 | Ascites | Hu | E, ICC/IF, P, WB |
0.1 ml /
€380.00
|
| OriGene Technologies GmbH | |||||||
+3 additional images |
Highly validated antibody! |
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| TA312001 | MDM4 antibody |
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| Rabbit polyclonal MDM4 (Ser367) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505707 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI2B8 (formerly 2B8) | |||||||
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Mouse | IgG2a | OTI2B8 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA505712 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10) | |||||||
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Mouse | IgG1 | OTI4E10 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505724 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI3B9 (formerly 3B9) | |||||||
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Mouse | IgG2b | OTI3B9 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA505725 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI3A6 (formerly 3A6) | |||||||
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Mouse | IgG2b | OTI3A6 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA505726 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4G3 (formerly 4G3) | |||||||
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Mouse | IgG2b | OTI4G3 | Purified | Hu | P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505727 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4D2 (formerly 4D2) | |||||||
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Mouse | IgG2b | OTI4D2 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505732 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI1E8 (formerly 1E8) | |||||||
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Mouse | IgG1 | OTI1E8 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505733 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI4B10 (formerly 4B10) | |||||||
![]() |
Mouse | IgG1 | OTI4B10 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA505734 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C9 (formerly 2C9) | |||||||
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Mouse | IgG1 | OTI2C9 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA505749 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI2E11 (formerly 2E11) | |||||||
![]() |
Mouse | IgG1 | OTI2E11 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA505750 | MDM4 antibody |
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| MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C1 (formerly 2C1) | |||||||
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Mouse | IgG1 | OTI2C1 | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| AM26541AF-S | MDM4 pSer367 antibody |
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Mouse | IgG2b | #15 | Azide Free | Hu, Ms | WB |
50 µg /
€460.00
|
| OriGene Technologies GmbH | |||||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR207830L2V | Lenti ORF particles, Mdm4 (GFP-tagged) - Mouse transformed mouse 3T3 cell double minute 4 (Mdm4), 200 uL, >10^7 TU/mL |
|
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200 µl /
€1,180.00
|
|
| OriGene Technologies, Inc. | ||








+3 additional images


















