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MED24 antibody

Principal name

MED24 antibody

Alternative names for MED24 antibody

ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100, Mediator complex 24, CRSP complex 4, Mediator of RNA polymerase II transcription subunit 24, Thyroid hormone receptor-associated protein complex 100 kDa component, Thyroid hormone receptor-associated protein 4, Vitamin D3 receptor-interacting protein complex component DRIP100, Activator-recruited cofactor 100 kDa component, Cofactor required for Sp1 transcriptional activation subunit 4

SwissProt ID

O75448 (Human), Q4V8B3 (Rat), Q5F3M0 (Chick), Q99K74 (Mouse)

Gene ID

9862 (MED24), 23989 (Med24), 619436

Ncbi ID

9606, NP_001072986.1, NP_035999.2, NM_014815, NP_055630, NM_011869, NM_001034079, NM_001079518

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of MED24 antibody

In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size from 20 to 240 kDa, including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, and they are characterized by the presence of a nuclear receptor recognition motif, which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR-induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.