MYD88 antibody
Principal name
MYD88 antibody
Alternative names for MYD88 antibody
Myeloid differentiation primary response protein MyD88
Ncbi ID
NP_001166037.1, 9606, NP_002459, AAH13589.1, U70451, NP_034981.1, NM_010851, NM_001172569, NM_001172568, NM_001172567
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of MYD88 antibody
The mammalian host defense system is essentially regulated by Toll-like receptor (TLR) family. Toll-like receptors (TLRs) play an important role in recognition of microbial components and induction of innate immunity. At least 10 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM). Most of the TLRs are dependent on the expression of adapter molecules MyD88 for all their function, the TL3 and TLR 4 are unique in their ability to mediate both MyD88-dependent and independent reposes (1). The MyD88 independent pathway involves induction of a DC maturation and induction of type 1 interferon (IFN-B).
Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to ’death-domains’, is rapidly up-regulated during differentiation of the myeloleukemic cell line M1. The murine MyD88 is 53 amino acids larger than human MyD88 and maps to chromosome 3p21.3-p22. The over expression of death region in MyD88 lead to transcriptional activation of IL-8 promoter. The microbial components trigger the activation of two downstream signaling pathways of TLRs; MyD88- and/or TRIF-dependent pathways leading to activation of NF-kappaB. The MyD88 transduces a core set of Toll-like receptor (TLR)-induced signals, microbial-induced host responses are divided broadly into the MyD88-dependent and MyD88-independent pathways. The specific pathogen induced early host responses are generally mediated by MyD88 dependent pathways. Inhaled endotoxins induce an acute inflammatory response in the airways mediated through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88). The endotoxin-induced acute bronchoconstriction, vascular damage resulting in protein leak, Th1 cytokine and chemokine secretion and neutrophil recruitment in the airways are abrogated in mice deficient for either TIRAP or MyD88, but not in TRIF deficient mice (2). The bronchoconstriction and acute inflammatory lung pathology mediated by TLR-4 to inhaled endotoxins critically dependent on the expression and co-operative role of adaptor proteins, TIRAP and MyD88 (3). The MyD88 mediated post-TLR signaling is also involved in a number of allergents and endotoxins.
General readings
Wiens M, Korzhev M, Krasko A, Thakur N, Perovi-Ottstadt S, Breter H, Ushijima H, Diehl-Seifert B, Müller I, Müller WEG (2005) Innate immune defense of the sponge Suberites domuncula against bacteria involves a MyD88-dependent signalling pathway: Induction of a perforin-like molecule. J. Biol. Chem. 280: 27949-27959.



























































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- Cited (1)
- Highly Validated (4)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA502104 | MYD88 antibody |
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| MYD88 mouse monoclonal antibody, clone OTI1B4 (formerly 1B4) | |||||||
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Mouse | IgG2a | OTI1B4 | Purified | Hu | F, ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Top Selling product! Highly validated antibody! |
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| TA502117 | MYD88 antibody |
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| MYD88 mouse monoclonal antibody, clone OTI2B2 (formerly 2B2) | |||||||
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Mouse | IgG2a | OTI2B2 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+9 additional images |
Top Selling product! Published recently! Highly validated antibody! |
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| TA502116 | MYD88 antibody |
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| MYD88 mouse monoclonal antibody, clone OTI1A10 (formerly 1A10) | |||||||
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Mouse | IgG2a | OTI1A10 | Purified | Hu | F, P, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+6 additional images |
Highly validated antibody! |
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| TA502118 | MYD88 antibody |
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| MYD88 mouse monoclonal antibody, clone OTI1B8 (formerly 1B8) | |||||||
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Mouse | IgG1 | OTI1B8 | Purified | Hu, Mky, Rt | F, ICC/IF, P, WB |
0.1 ml /
€379.00
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
Highly validated antibody! |
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| TA302999 | MYD88 antibody |
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| Goat Polyclonal Antibody against MYD88 | |||||||
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Goat | Aff - Purified | Can, Chimp, Hu, Ms, Rt | E, P, WB |
0.1 mg /
€360.00
|
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| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA305998 | MYD88 antibody |
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| Rabbit Polyclonal MYD88 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms | E, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA305999 | MYD88 (C-term) antibody |
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| Rabbit Polyclonal MYD88 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA319687 | MYD88 (176-280) antibody |
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| Mouse MyD88 Monoclonal Antibody | |||||||
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Mouse | IgG | 2E9C2 | Aff - Purified | Hu, Ms | E, P, WB |
0.1 mg /
€415.00
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA324013 | MYD88 antibody |
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| Anti-MYD88 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA326877 | MYD88 antibody |
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| Rabbit anti-MyD88 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
|
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| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA327950 | MYD88 (C-term) antibody |
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| Rabbit Polyclonal anti-MyD88 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms | WB |
0.1 ml /
€255.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA336449 | MYD88 antibody |
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| Rabbit Polyclonal MyD88 Antibody | |||||||
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Rabbit | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€415.00
|
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| OriGene Technologies, Inc. | |||||||
| TA337031 | MYD88 antibody |
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| Rabbit Polyclonal MyD88 Antibody | |||||||
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Rabbit | Purified | Hu, Ms | WB |
0.1 mg /
€335.00
|
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| OriGene Technologies, Inc. | |||||||
| TA337167 | MYD88 antibody |
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| Mouse Monoclonal MyD88 Antibody (4D6) | |||||||
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Mouse | 4D6 | Purified | Hu | F, ICC/IF, WB |
0.1 mg /
€475.00
|
|
| OriGene Technologies, Inc. | |||||||
+4 additional images |
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| AP02277SU-N | MYD88 antibody |
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Rabbit | Serum | C, E, WB |
0.1 ml /
€510.00
|
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| OriGene Technologies GmbH | |||||||
| AP02277SU-S | MYD88 antibody |
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Rabbit | Serum | C, E, WB |
20 µl /
€150.00
|
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| OriGene Technologies GmbH | |||||||
| AP07327PU-N | MYD88 antibody |
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Rabbit | Aff - Purified | Hu | P, WB |
50 µg /
€425.00
|
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| OriGene Technologies GmbH | |||||||
| AP08396PU-N | MYD88 (233-248) antibody |
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Rabbit | IgG | Aff - Purified | Hu, Ms | P, WB |
50 µg /
€425.00
|
|
| OriGene Technologies GmbH | |||||||
| AP18123PU-N | MYD88 antibody |
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Rabbit | Hu, Ms | WB |
0.4 ml /
€415.00
|
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| OriGene Technologies GmbH | |||||||
| AP20639PU-N | MYD88 antibody |
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![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | P, WB |
0.1 mg /
€370.00
|
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| OriGene Technologies GmbH | |||||||
+1 additional image |
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+4 additional images










![Western Blot: MyD88 Antibody [TA336449] - Analysis of MyD88 in human spleen cell lysate using 0.5 ug/ml of TA336449.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB100-56698-1-W.jpg)
![Western Blot: MyD88 Antibody [TA337031] - Analysis of MyD88 using MyD88 antibody. Human Ramos cell lysate probed using MyD88 antibody at 4 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NBP2-24671-1-W.jpg)
![Western Blot: MyD88 Antibody (4D6) [TA337167] - Analysis of MyD88 in A) human ovary, B) human prostate and Jurkat cell lysate in the C) absence and D) presence of immunizing peptide using this antibody. Goat anti-mouse Ig HRP secondary antibody and PicoTe](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NBP2-27369-1-W.jpg)




