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NDRG1 antibody

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Principal name

NDRG1 antibody

Alternative names for NDRG1 antibody

CAP43, DRG1, DRG-1, RTP, Rit42, N-myc downstream-regulated gene 1 protein, Nickel-specific induction protein Cap43, Differentiation-related gene 1 protein, Reducing agents and tunicamycin-responsive protein

SwissProt ID

Q3SYX0 (Bovin), Q62433 (Mouse), Q6JE36 (Rat), Q92597 (Human)

Gene ID

10397 (NDRG1), 17988 (Ndrg1), 299923

Ncbi ID

9606, NP_006087, NP_001128714, NP_032707.2, NP_001128714.1, NM_001135242, NP_006087.2, NM_008681, NM_001011991, NM_006096

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of NDRG1 antibody

N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival. NDRG1 is ubiquitously expressed and highly responsive to a variety of stress sigls including D damage, hypoxia, and elevated levels of nickel and calcium. Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc. During D damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis. Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis. Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axol survival. NDRG1 is up-regulated during mast cell maturation and its deletion leads to attenuated allergic responses. Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known. NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.

General readings

Richardson DR., et al. (2008) Biochim Biophys Acta. 1783(10):1981-92.
Costa M., et al. (2008) Carcinogenesis. 29(1):2-8.

H00010397-M03 - NDRG1
Immunoperoxidase of monoclonal antibody to NDRG1 on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 0.7 ug/ml]
H00010397-M03 - NDRG1
Immunofluorescence of monoclonal antibody to NDRG1 on HeLa cell . [antibody concentration 10 ug/ml]
H00010397-M03 - NDRG1
Detection limit for recombinant GST tagged NDRG1 is approximately 1ng/ml as a capture antibody.
PAB6284 - NDRG1
NDRG1 polyclonal antibody ( Cat # PAB6284 ) staining ( 0.1 µg/ml ) of human kidney lysate ( RIPA buffer, 35 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
ARP47974_T100 - NDRG1
Human HepG2; WB Suggested Anti-NDRG1 Antibody Titration: 2.5ug/ml. Positive Control: HepG2 cell lysate; NDRG1 antibody - C-terminal region (ARP47974_T100) in Human HepG2 cells using Western Blot
ARP47975_T100 - NDRG1
Human HepG2; WB Suggested Anti-NDRG1 Antibody Titration: 2.5ug/ml. Positive Control: HepG2 cell lysate; NDRG1 antibody - N-terminal region (ARP47975_T100) in Human HepG2 cells using Western Blot
AR09269PU-L - NDRG1
AR09269PU-L - NDRG1
Recombinant human NDRG1, 1-394 aa, His-tagged: 15% SDS-PAGE (3 µg)
AP17582PU-N - NDRG1
Western blot analysis of NDRG1 Antibody (N-term) (AP17582PU-N) in MDA-MB231 cell line lysates (35ug/lane). NDRG1 (arrow) was detected using the purified Pab.
AP23025PU-N - NDRG1
Immunohistochemistry Image: Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
AP23025PU-N - NDRG1
Immunohistochemistry Image: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
AP23025PU-N - NDRG1
Western Blot Image: Antibody staining (0.1 µg/ml) of Human Kidney lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
TP301374 - NDRG1
TP325609 - NDRG1
TA302840 - NDRG1
TA302840 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
TA321744 - NDRG1
Predicted band size: 43 kDa . Positive control: Human lymphoma tissue lysate. Recommended dilution: 1/500-2000
TA321744 - NDRG1
Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NDRG1 antibody at dilution 1/70, on the right is treated with the synthetic peptide. (Original magnification: x200)
TA327295 - NDRG1
Western blot analysis of extracts of various cell lines, using NDRG1 antibody.
TA327295 - NDRG1
Immunohistochemistry of paraffin-embedded mouse lung using NDRG1 antibody at dilution of 1:100 (400x lens).
TA327295 - NDRG1
Immunohistochemistry of paraffin-embedded rat brain using NDRG1 antibody at dilution of 1:100 (400x lens).
TA327295 - NDRG1
Immunohistochemistry of paraffin-embedded rat kidney using NDRG1 antibody at dilution of 1:100 (400x lens).
TA327295 - NDRG1
Immunofluorescence analysis of MCF7 cell using NDRG1 antibody. Blue: DAPI for nuclear staining.
TA342549 - NDRG1
WB Suggested Anti-NDRG1 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate
TA342550 - NDRG1
WB Suggested Anti-NDRG1 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate
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  2. Highly Validated (1)

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NDRG1 antibody
  Rabbit anti-NDRG1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NDRG1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €335.00
  OriGene Technologies, Inc.
+4 additional images

Highly validated antibody!

NDRG1 (C-term) antibody
  Goat Polyclonal Antibody against NDRG1  
TA302840 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

NDRG1 antibody
  Anti-NDRG1 Rabbit Polyclonal Antibody  
Predicted band size: 43 kDa . Positive control: Human lymphoma tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

NDRG1 (N-term) antibody
Western blot analysis of NDRG1 Antibody (N-term) (AP17582PU-N) in MDA-MB231 cell line lysates (35ug/lane). NDRG1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

NDRG1 (C-term) antibody
Immunohistochemistry Image: Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Purified Hu, Rb E, P, WB
50 µg / €425.00
  OriGene Technologies GmbH
+2 additional images

NDRG1 antibody
NDRG1 Rabbit Serum Ms C, E, WB
0.2 ml / €430.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NDRG1 (transcript variant 2)
  Recombinant protein of human N-myc downstream regulated 1 (NDRG1), transcript variant 2  
NDRG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

NDRG1 (transcript variant 1)
  Recombinant protein of human N-myc downstream regulated 1 (NDRG1), transcript variant 1  
NDRG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

Lysates

Catalog No.    

NDRG1 overexpression lysate
NDRG1 overexpression lysate  
0.1 mg / €315.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ndrg1 (GFP-tagged) - Mouse N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ndrg1 (GFP-tagged) - Mouse N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Ndrg1 (Myc-DDK-tagged) - Mouse N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ndrg1 (Myc-DDK-tagged) - Mouse N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ndrg1 (GFP-tagged ORF) - Rat N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ndrg1 (GFP-tagged ORF) - Rat N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Ndrg1 (Myc-DDK-tagged ORF) - Rat N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ndrg1 (Myc-DDK-tagged ORF) - Rat N-myc downstream regulated gene 1 (Ndrg1), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

13 Item(s)

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13 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. Lysate (1)
  2. Mouse Lenti ORF Particle (2)
  3. Primary Antibody (6)
  4. Protein | Growth Factor (2)
  5. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (6)
Target
  1. NDRG1 (8)
Property
  1. C-term (2)
  2. N-term (1)
Reactivity
  1. Human (Hu) (5)
  2. Mouse (Ms) (4)
  3. Rat (Rt) (3)
  4. Canine (Can) (1)
  5. Rabbit (Rb) (1)
Applications
  1. Western blot / Immunoblot (WB) (5)
  2. Enzyme Immunoassay (E) (3)
  3. Paraffin Sections (P) (2)
  4. Frozen sections (C) (1)
Presentation
  1. Purified (3)
  2. Aff - Purified (1)
  3. Serum (1)
Host
  1. Rabbit (4)
  2. Goat (2)
Images
  1. 1 image (7)
  2. 3+ images (2)
  3. 5+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (5)
  2. IHC (2)
  3. Immunofluorescence (IF) (1)
  4. Paraffin Sections (P) (1)
Species (Protein)
  1. Human (2)
Source
  1. HEK293 cells (2)
Manufacturer
  1. OriGene Technologies (13)
Service
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