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Neurotrypsin antibody

Principal name

Neurotrypsin antibody

Alternative names for Neurotrypsin antibody

PRSS12, Serine protease 12, Motopsin, Leydin

SwissProt ID

P56730 (Human)

Gene ID

8492 (PRSS12)

Ncbi ID

9606, NP_003610.2, NP_003610, CAA04816

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Neurotrypsin antibody

Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator.
There are three sequences published for neurotrypsin to date; 875, 834 and 505 amino acids in length. The predicted masses are 97, 92.5 and 55.7 kDa respectively, with predicted pI of 9.14, 8.88 and 6.57. The three forms all start at the same place. The 505 residue form terminates in the last SRCR domain, before the catalytic domain, and the 834 amino acid form has a 40 amino acid deletion that starts just after the PC site, and includes the catalytic histidine, thus both species would be proteolytically inactive.

Western Blot analysis of PRSS12 expression in transfected 293T cell line (H00008492-T01) by PRSS12 MaxPab polyclonal antibody.Lane 1: PRSS12 transfected lysate(55.55 KDa).Lane 2: Non-transfected lysate.

H00008492-B01

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, Cerebellum.

AP07724PU-N

Immunohistochemistry of PRSS12 in human brain tissue with PRSS12 polyclonal antibody ( Cat # PAB12990 ) at 2.5 µg/ml.

PAB12990

Western blot analysis of PRSS12 in SK-N-SH cell lysate with PRSS12 polyclonal antibody ( Cat # PAB12990 ) at ( A ) 0.5, ( B ) 1 and ( C ) 2 µg/ml.

PAB12990

Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

TA306416

Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 ug/ml.

TA306416

Immunofluorescence of Neurotrypsin in Human Brain cells with Neurotrypsin antibody at 20 ug/mL.

TA306416

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA306416	Neurotrypsin (N-term) antibody
	Rabbit Polyclonal Neurotrypsin Antibody
	Rabbit	IgG	Aff - Purified	Hu, Ms, Rt	E, P, WB	0.1 mg / €415.00
						OriGene Technologies, Inc.
+2 additional images
AP07724PU-N	Neurotrypsin antibody
	Rabbit		Purified	Hu, Ms, Rt	P, WB	50 µg / €425.00
						OriGene Technologies GmbH
RA30051-50	Neurotrypsin antibody
	Rabbit	IgG	Aff - Purified	Hu, Ms, Rt	P, WB	50 µg / €530.00
						Neuromics Antibodies

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